ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2011
Major locus and other novel additive and epistatic loci involved in modulation of isoflavone concentration in soybean seeds.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 81 citations in OpenAlex.
- Integrative QTL mapping and candidate gene analysis for main stem node number in soybean.BMC plant biology · 2025Article
- High-Density Genetic Map Construction and Quantitative Trait Locus Analysis of Fruit- and Oil-Related Traits inInternational journal of molecular sciences · 2024Article
- Identification of Genes Responsible for the Synthesis of Glycitein Isoflavones in Soybean Seeds.Plants (Basel, Switzerland) · 2024Article
- QTL mapping reveals key factors related to the isoflavone contents and agronomic traits of soybean (Glycine max).BMC plant biology · 2023Article
- Identification of major quantitative trait loci and candidate genes for seed weight in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Identification of genetic loci conferring seed coat color based on a high-density map in soybean.Frontiers in plant science · 2022Article
- Genome wide association study to detect genetic regions related to isoflavone content in a mutant soybean population derived from radiation breeding.Frontiers in plant science · 2022Article
- Fine-Mapping and Functional Analyses of a Candidate Gene Controlling Isoflavone Content in Soybeans Seed.Frontiers in plant science · 2022Article
- The Soybean High Density 'Forrest' by 'Williams 82' SNP-Based Genetic Linkage Map Identifies QTL and Candidate Genes for Seed Isoflavone Content.Plants (Basel, Switzerland) · 2021Article
- Novel QTL and Meta-QTL Mapping for Major Quality Traits in Soybean.Frontiers in plant science · 2021Article
- Single-base deletion inBreeding science · 2020Article
- Identification and characterization of a major QTL underlying soybean isoflavone malonylglycitin content.Breeding science · 2019Article
- Deciphering the Genetic Architecture of Plant Height in Soybean Using Two RIL Populations Sharing a CommonPlants (Basel, Switzerland) · 2019Article
- QTL mapping pod dehiscence resistance in soybean (Glycine max L. Merr.) using specific-locus amplified fragment sequencing.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Article
- Whole-genome mapping identified novel "QTL hotspots regions" for seed storability in soybean (Glycine max L.).BMC genomics · 2019Article
- Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits.International journal of molecular sciences · 2019Review
- Genome-Wide Detection of Major and Epistatic Effect QTLs for Seed Protein and Oil Content in Soybean Under Multiple Environments Using High-Density Bin Map.International journal of molecular sciences · 2019Article
- Utilization of Interspecific High-Density Genetic Map of RIL Population for the QTL Detection and Candidate Gene Mining for 100-Seed Weight in Soybean.Frontiers in plant science · 2019Article
- Acid phosphatase gene GmHAD1 linked to low phosphorus tolerance in soybean, through fine mapping.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Fine-mapping of QTLs for individual and total isoflavone content in soybean (Glycine max L.) using a high-density genetic map.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Seeds of soybean [Glycine max (L.) Merr.] accumulate more isoflavones than any tissue of any plant species. In other plant parts, isoflavones are usually released to counteract the effects of various biotic and abiotic stresses. Because of the benefits to the plant and positive implications that consumption may have on human health, increasing isoflavones is a goal of many soybean breeding programs. However, altering isoflavone levels through marker-assisted selection (MAS) has been impractical due to the small and often environmentally variable contributions that each individual quantitative trait locus (QTL) has on total isoflavones. In this study, we developed a Magellan × PI 437654 F(7)-RIL population to construct a highly saturated non-redundant linkage map that encompassed 451 SNP and SSR molecular markers and used it to locate genomic regions that govern accumulation of isoflavones in the seeds of soybean. Five QTLs were found that contribute to the concentration of isoflavones, having single or multiple additive effects on isoflavone component traits. We also validated a major locus which alone accounted for up to 10% of the phenotypic variance for glycitein, and 35-37% for genistein, daidzein and the sum of all three soybean isoflavones. This QTL was consistently associated with increased concentration of isoflavones across different locations, years and crosses. It was the most important QTL in terms of net increased amounts of all isoflavone forms. Our results suggest that this locus would be an excellent candidate to target for MAS. Also, several minor QTLs were identified that interacted in an additive-by-additive epistatic manner, to increase isoflavone concentration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.