ArticleCancer immunology, immunotherapy : CII2012
Widespread expressions of immunoglobulin superfamily proteins in cancer cells.
Article in Cancer immunology, immunotherapy : CII, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Preclinical pharmacokinetic modeling and clinical translation of SIG001, a novel anti-cancer therapeutic antibody targeting on cancer-derived sialylated IgG.Frontiers in pharmacology · 2026Article
- Immunoglobulin superfamily 9 (IGSF9) is trans-activated by p53, inhibits breast cancer metastasis via FAK.Oncogene · 2022Article
- Lung cell membrane-coated nanoparticles capable of enhanced internalization and translocation in pulmonary epithelial cells.International journal of pharmaceutics · 2022Article
- Cancer IgG, a potential prognostic marker, promotes colorectal cancer progression.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Cancer cell-derived immunoglobulin G activates platelets by binding to platelet FcγRIIa.Cell death & disease · 2019Article
- ProtLID, a Residue-Based Pharmacophore Approach to Identify Cognate Protein Ligands in the Immunoglobulin Superfamily.Structure (London, England : 1993) · 2016Article
- Should EMT of Cancer Cells Be Understood as Epithelial-Myeloid Transition?Journal of Cancer · 2014Review
- Neuron-derived IgG protects neurons from complement-dependent cytotoxicity.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2013Article
- CA215 and GnRH receptor as targets for cancer therapy.Cancer immunology, immunotherapy : CII · 2012Article
- IgG expression in human colorectal cancer and its relationship to cancer cell behaviors.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RP215 monoclonal antibody (Mab) was shown to recognize a carbohydrate-associated epitope of cancer cell-expressed glycoproteins, known as CA215. Extensive MALDI-TOF MS analysis was performed to search for the molecular identity of CA215. Besides immunoglobulin (Ig) heavy chains, homology to human T-cell receptors (TCR) and Ig-like cell adhesion molecules was also detected. By using RT-PCR and cDNA sequencing, it was observed that as many as 80% of cancer cell lines showed significant levels of gene expressions of TCR-α and TCR-β. Selected Ig-like cell adhesion molecules such as CD47, CD54, CD58 and CD 147 were also highly expressed among all the cell lines tested. In contrast, co-receptors and co-stimulators of TCR such as CD3, CD4 and CD8 were rarely expressed demonstrating the non-functional nature of TCR in cancer cells. Results of immunohistochemical staining and Western blot assays of cancer cell lines as well as cancerous tissue sections were consistent with these observations. Anti-TCR and anti-human IgG antibodies were shown to induce complement-dependent cytotoxicity and apoptosis of cultured cancer cells indicating the surface nature of Ig-like proteins. Based on these experimental observations, it was hypothesized that the expressions of these immunoglobulin superfamily (IgSF) proteins may be relevant to the immune protection and proliferations of cancer cells during carcinogenesis or cancer progression. Surface-bound TCR-like proteins as well as immunoglobulins may be the potential targets for RP215-based anti-cancer drugs.
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