ReviewDer Pathologe2011
[Carcinoma in situ of the testis: predisposition, evolution and early detection].
Review in Der Pathologe, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carcinoma in situ (CIS), also known as intratubular germ cell neoplasia unclassified, is the common obligate precursor lesion of malignant testicular seminomatous and non-seminomatous germ cell tumors (GCT), which show a steadily increasing incidence in Europe. Although GCT is a potentially curable cancer with excellent prognosis even in patients with organ metastasis, many patients suffer from chemotherapy-associated effects and some develop a secondary (non-germ cell) malignancy. Recently, genome-wide association studies revealed genetic predispositions linked to six genes (KITL, SPRY4, BAK1, TERT, ATF7IP, DMRT1). Exposure to environmental factors was also linked to increased prevalence of testicular dysgenesis and CIS/GCT by the action of hormone disruptors on embryonal gonadal tissue during pregnancy. By unknown mechanisms these genetic and environmental factors might create a disturbed microenvironment in the fetal testis leading to survival of embryonic germ cells and subsequent malignant transformation might result in CIS. Molecular pathways involved in this process include activated cKIT pathway and LIN28 associated deregulation of miRNA targets. The challenge for the future is to identify high risk patients prior to invasive GCT, to develop non-invasive tests for detection of CIS on seminal material and elucidate the precise role of the microenvironment in CIS initiation.
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Registered trials
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