SynthesisJournal of cancer research and clinical oncology2011
Diagnosis value of focal liver lesions with SonoVue®-enhanced ultrasound compared with contrast-enhanced computed tomography and contrast-enhanced MRI: a meta-analysis.
Synthesis in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Comparative Diagnostic Accuracy of Contrast-Enhanced Ultrasound and Shear Wave Elastography in Differentiating Benign and Malignant Lesions: A Network Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Contrast-enhanced US for characterization of focal liver lesions: a comprehensive meta-analysis.European radiology · 2018Pooled it
- [Expert consensus on the diagnosis, treatment, and management of liver nodules (version 2026)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Article
- Research Progress on Contrast-Enhanced Ultrasound (CEUS) Assisted Diagnosis and Treatment in Liver-Related Diseases.International journal of medical sciences · 2025Review
- Ultrasomics differentiation of malignant and benign focal liver lesions based on contrast-enhanced ultrasound.BMC medical imaging · 2024Article
- WFUMB Review Paper. Incidental Findings in Otherwise Healthy Subjects, How to Manage: Liver.Cancers · 2024Review
- The comparison of contrast-enhanced ultrasound and gadoxetate disodium-enhanced MRI LI-RADS for nodules ≤2 cm in patients at high risk for HCC: a prospective study.Frontiers in oncology · 2024Article
- High Frame Rate Contrast-enhanced Ultrasound Helps Differentiate Malignant and Benign Focal Liver Lesions.Journal of clinical and translational hepatology · 2022Article
- Contrast-enhanced ultrasonography for the evaluation of malignant focal liver lesions.Ultrasonography (Seoul, Korea) · 2022Article
- Protocol of Kupffer phase whole liver scan for metastases: A single-center prospective study.Frontiers in medicine · 2022Article
- Contrast Agents for Hepatocellular Carcinoma Imaging: Value and Progression.Frontiers in oncology · 2022Review
- Multiparametric Ultrasound Approach Using a Tree-Based Decision Classifier for Inconclusive Focal Liver Lesions Evaluated by Contrast Enhanced Ultrasound.Journal of personalized medicine · 2021Article
- New frontiers in liver ultrasound: From mono to multi parametricity.World journal of gastrointestinal oncology · 2021Review
- Contrast-enhanced ultrasound LI-RADS 2017: comparison with CT/MRI LI-RADS.European radiology · 2021Article
- Hepatocellular Carcinoma: State of the Art Imaging and Recent Advances.Journal of clinical and translational hepatology · 2019Review
- The Role of US Contrast Agents in US-Guided Biopsy of Focal Liver Lesions: A Pictorial Review.Ultrasound international open · 2019Review
- Contrast-enhanced ultrasonography of the liver using SonoVue.Ultrasonography (Seoul, Korea) · 2018Review
- Light and sound - emerging imaging techniques for inflammatory bowel disease.World journal of gastroenterology · 2016Review
- International guidelines for contrast-enhanced ultrasonography: ultrasound imaging in the new millennium.Ultrasonography (Seoul, Korea) · 2016Review
- Ultrasound imaging of the liver and bile ducts - expectations of a clinician.Journal of ultrasonography · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposesThis study is aimed at evaluating diagnostic value of focal liver lesions (FLLs) with SonoVue(®)-enhanced ultrasound compared with contrast-enhanced computed tomography (CECT) and contrast-enhanced magnetic resonance imaging (CEMRI).
methodsPubMed, EMBASE, and the Cochrane Central Register were searched for English language articles published from January 2000 to May 2011. Histopathologic analysis and/or close clinical and imaging follow-up (except CECT or CEMRI) for at least 6 months were used as golden reference. Sensitivity, specificity, summary receiver operating characteristic (SROC) curves, and area under the curve (AUC) were extracted to test heterogeneity.
resultsIn 21 included studies, for the SonoVue(®)-enhanced ultrasound studies, sensitivity was 88% (95% CI 87-90), specificity was 81% (95% CI 79-84), and 38.62 (95% CI 13.64-109.35) for diagnostic odds ratio (DOR); for the CECT studies, sensitivity was 90% (95% CI 88-92), specificity was 77% (95% CI 71-82), and 30.84 (95% CI 11.11-85.61) for DOR; for the CEMRI studies, sensitivity was 86% (95% CI 83-88), specificity was 81% (95% CI 76-85), and 27.63 (95% CI 11.28-67.70) for DOR.
conclusionsIn comparison, SonoVue(®)-enhanced ultrasound had high pooled sensitivity and pooled specificity. SROC analysis showed the diagnostic value of FLLs with SonoVue(®)-enhanced ultrasound has no significant difference compared with CECT and CEMRI. SonoVue(®)-enhanced ultrasound is highly sensitive and specific in the characterization of FLLs to support an effective diagnostic method.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.