ArticleMolecular vision2011
Increased tumor necrosis factor-α, cleaved caspase 3 levels and insulin receptor substrate-1 phosphorylation in the β₁-adrenergic receptor knockout mouse.
Article in Molecular vision, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- A regulatory role for β-adrenergic receptors regarding the resolvin D1 (RvD1) pathway in the diabetic retina.PloS one · 2017Article
- β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.Investigative ophthalmology & visual science · 2017Article
- Etanercept restores normal insulin signal transduction in β2-adrenergic receptor knockout mice.Journal of neuroinflammation · 2014Article
- Propranolol inhibits growth of hemangioma-initiating cells but does not induce apoptosis.Pediatric research · 2014Article
- Intravitreal injection of IGFBP-3 restores normal insulin signaling in diabetic rat retina.PloS one · 2014Article
- β1-adrenergic receptor stimulation by agonist Compound 49b restores insulin receptor signal transduction in vivo.Molecular vision · 2014Article
- TNFα inhibits IGFBP-3 through activation of p38α and casein kinase 2 in human retinal endothelial cells.PloS one · 2014Article
- IGFBP-3 and TNF-α regulate retinal endothelial cell apoptosis.Investigative ophthalmology & visual science · 2013Article
- Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.JAMA ophthalmology · 2013Article
- Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions.Molecular vision · 2013Article
- Article
- Role of β-adrenergic receptor regulation of TNF-α and insulin signaling in retinal Muller cells.Investigative ophthalmology & visual science · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the role of β1-adrenergic receptors on insulin like growth factor (IGF)-1 receptor signaling and apoptosis in the retina using β1-adrenergic receptor knockout (KO) mice.
methodsWestern blotting and enzyme-linked immunosorbent assay analyses were done on whole retinal lysates from β1-adrenergic receptor KO mice and wild-type littermates. In addition, vascular analyses of degenerate capillaries and pericyte ghosts were done on the retina of the β1-adrenergic receptor KO mice versus littermates.
resultsLack of β1-adrenergic receptors produced a significant increase in both degenerate capillaries and pericyte ghosts. This was accompanied by an increase in cleaved caspase 3 and tumor necrosis factor α levels. IGF-1 receptor phosphorylation was not changed; however, protein kinase B (Akt) phosphorylation was significantly decreased. The decrease in Akt phosphorylation is likely caused by increased insulin receptor substrate-1 serine 307 (IRS-1(Ser307)) phosphorylation, which is inhibitory to IGF-1 receptor signaling.
conclusionsThese studies further support the idea that maintenance of β-adrenergic receptor signaling is beneficial for retinal homeostasis. Loss of β1-adrenergic receptor signaling alters tumor necrosis factor α and apoptosis levels in the retina, as well as Akt and IGF-1 receptor phosphorylation. Since many of these same changes are observed in the diabetic retina, these data support that novel β-adrenergic receptor agents may provide additional avenues for therapeutics.
Indexed as
Identifiers
21850156PMC3137556W2148149909What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.