Evidence map›Paper›PMID 21850045›Full record

ReviewNature reviews. Genetics2011

Advances in prenatal screening: the ethical dimension.

Antina de Jong, Wybo J Dondorp, Suzanna G M Frints, Christine E M de Die-Smulders, Guido M W R de Wert

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Prenatal genetic testing for cystic fibrosis: a systematic review of clinical effectiveness and an ethics review.Genetics in medicine : official journal of the American College of Medical Genetics · 2020
    Pooled it
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  17. Ethical issues in preconception genetic carrier screening.Upsala journal of medical sciences · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Antina de JongDepartment of Health, Ethics and Society, Maastricht University, PO BOX 616, 6200 MD Maastricht, The Netherlands. at.dejong@maastrichtuniversity.nl
Wybo J Dondorp
Suzanna G M Frints
Christine E M de Die-Smulders
Guido M W R de Wert

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prenatal screening strategies are undergoing rapid changes owing to the introduction of new testing techniques. The overall tendency is towards broadening the scope of prenatal testing through increasingly sensitive ultrasound scans and genome-wide molecular tests. In addition, non-invasive prenatal diagnosis is likely to be introduced in the near future. These developments raise important ethical questions concerning meaningful reproductive choice, the autonomy rights of future children, equity of access and the proportionality of testing.

Indexed as

Chromosome AberrationsAbortion, EugenicAneuploidyChildEthics, MedicalFemaleGenetic Association StudiesGenetic TestingHumansInfant, NewbornKaryotypingNeonatal ScreeningPatient RightsPregnancyPrenatal DiagnosisSequence Analysis, DNA

Identifiers

PMID21850045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.