Evidence map›Paper›PMID 21850042›Full record

ReviewNature reviews. Genetics2011

Dynamic interactions between transposable elements and their hosts.

Henry L Levin, John V Moran

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 344 papers.

0numbers the graph read from it
0cells of the map it votes in
344citing papers in PubMed
52.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

344 citing papers in PubMed, 620 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Tumor cell intrinsic mechanisms of immune escape.Cell communication and signaling : CCS · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Transposon Regulation in thebioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

284 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Henry L LevinSection on Eukaryotic Transposable Elements, Laboratory of Gene Regulation and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. henry_levin@nih.gov
John V Moran
National Institutes of Health · USUniversity of Michigan–Ann Arbor · US

Funding

Regulation And Function Of RetroelementsZIAHD001009 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LEVIN, HENRY L. · 2009 to 2025
$21.8M
Gen. &Mol. Analysis of Human LINE-1 RetrotranspositionR01GM060518 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 1999 to 2024
$4.8M
LINE-1 Retrotransposition in Human Embryonic Stem CellsR01GM082970 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORAN, JOHN V. · 2008 to 2011
$1.0M
Howard Hughes Medical InstituteIntramural NIH HHS Z99 DA999999Intramural NIH HHS Z99 HD999999Intramural NIH HHS Z99 HL999999Intramural NIH HHS Z99 MH999999Intramural NIH HHS Z99 OD999999Intramural NIH HHS ZIA HD001009NIGMS NIH HHS GM060518NIGMS NIH HHS GM082970NIGMS NIH HHS R01 GM060518NIGMS NIH HHS R01 GM082970
6 · The paper itself

Abstract

Transposable elements (TEs) have a unique ability to mobilize to new genomic locations, and the major advance of second-generation DNA sequencing has provided insights into the dynamic relationship between TEs and their hosts. It now is clear that TEs have adopted diverse strategies - such as specific integration sites or patterns of activity - to thrive in host environments that are replete with mechanisms, such as small RNAs or epigenetic marks, that combat TE amplification. Emerging evidence suggests that TE mobilization might sometimes benefit host genomes by enhancing genetic diversity, although TEs are also implicated in diseases such as cancer. Here, we discuss recent findings about how, where and when TEs insert in diverse organisms.

Indexed as

DNA Transposable ElementsGenetic VariationDNA MethylationDNA RepairEpigenomicsEvolution, MolecularGenome, HumanGenome, PlantHeterochromatinHumansRNA, MessengerRNA, Small InterferingSequence Analysis, DNATelomereDNA Transposable ElementsHeterochromatinRNA, MessengerRNA, Small Interfering

Identifiers

PMID21850042
PMCPMC3192332
OpenAlexW2035260243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.