ArticleGenes and immunity2012
Rare mutations in TNFRSF13B increase the risk of asthma symptoms in Swedish children.
Article in Genes and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Unique and redundant roles of mouse BCMA, TACI, BAFF, APRIL, and IL-6 in supporting antibody-producing cells in different tissues.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spectrum of Disease Manifestations in Patients with Selective Immunoglobulin E Deficiency.Journal of clinical medicine · 2021Article
- The Epidemiology and Clinical Presentations of Atopic Diseases in Selective IgA Deficiency.Journal of clinical medicine · 2021Review
- Establishing the Molecular Diagnoses in a Cohort of 291 Patients With Predominantly Antibody Deficiency by Targeted Next-Generation Sequencing: Experience From a Monocentric Study.Frontiers in immunology · 2021Observational
- Selective IgA Deficiency a Probable Risk of Recurrent Chest Infections in Asthmatics.Journal of asthma and allergy · 2021Article
- Transcriptomic Analysis of Spleen Revealed Mechanism of Dexamethasone-Induced Immune Suppression in Chicks.Genes · 2020Article
- TACI deficiency leads to alternatively activated macrophage phenotype and susceptibility to Leishmania infection.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-β.Genes and immunity · 2014Review
- Risks for infection in patients with asthma (or other atopic conditions): is asthma more than a chronic airway disease?The Journal of allergy and clinical immunology · 2014Review
- IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.Human molecular genetics · 2014Article
- What does tympanostomy tube placement in children teach us about the association between atopic conditions and otitis media?Current allergy and asthma reports · 2014Review
- Genome-wide association study of lung function phenotypes in a founder population.The Journal of allergy and clinical immunology · 2014Article
- Asthma and risk of selective IgA deficiency or common variable immunodeficiency: a population-based case-control study.Mayo Clinic proceedings · 2013Article
- The BAFF/APRIL system: emerging functions beyond B cell biology and autoimmunity.Cytokine & growth factor reviews · 2013Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor) mutations seem to be associated with autoimmunity and common variable immunodeficiency in humans. Because of its role in immune responses, we investigated the association between TACI mutations and infection proneness/asthma symptoms in children. A total of 2372 children were genotyped for TACI mutations (I87N, C104R, S144X, A181E, R202H and ins204A). Serum IgA, IgG and specific IgE levels were determined in children with mutations. Data on parentally reported allergic diseases and infections were collected. In all, 55 individuals with TACI mutations were identified. Children with TACI mutations had a 2-fold increased risk of wheeze at 2 and 4 years of age and a 2.5-fold increased risk of asthma was seen at 4 years of age. None of the children with mutations suffered from IgA deficiency (<0.07 g l(-1)). No significant differences in serum IgG levels or specific IgE were found. Common variants in asthma susceptibility genes may account for up to 40% of cases of childhood-onset asthma, indicating a high contribution, compared with other common disorders. The role of rare variants/mutations in the pathogenesis of asthma is less clear. We conclude that mutations in TACI are the contributing factors for asthma symptoms in Swedish children, although the mechanisms still remain elusive.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.