ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2012
Influence of Alzheimer disease family history and genetic risk on cognitive performance in healthy middle-aged and older people.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults.The journal of prevention of Alzheimer's disease · 2024Pooled it
- Cognitive Functioning of Unaffected First-degree Relatives of Individuals With Late-onset Alzheimer's Disease: A Systematic Literature Review and Meta-analysis.Neuropsychology review · 2023Pooled it
- Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- Deficient Visuospatial Incidental and Intentional Memory in Cognitively Healthy Middle-Aged First-Degree Descendants of Alzheimer's Disease Patients.Brain sciences · 2026Article
- Apolipoprotein E e4 Status Predicts Memory Performance and Daily Functioning in Aging Hispanic/Latino Adults.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- The adaptation and evaluation of a culturally grounded lifestyle intervention to mitigate the risk of Alzheimer's disease and related dementias in Native Hawaiians and Pacific Islanders: A study protocol.SSM. Mental health · 2025Article
- Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Association between Multi-Domain Lifestyle and Objective Cognitive Impairment in Elderly People with SCD and MCI in Chinese Communities.Healthcare (Basel, Switzerland) · 2024Article
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity in REM sleep and verbal memory.Alzheimer's research & therapy · 2024Article
- Integration of polygenic and gut metagenomic risk prediction for common diseases.Nature aging · 2024Article
- Cognotoxemia: endotoxemia and gender predict changes in working memory performance in healthy adults.Frontiers in neuroscience · 2024Article
- Older adults at greater risk for Alzheimer's disease show stronger associations between sleep apnea severity and verbal memory.Research square · 2023Article
- Relationship between parental history of dementia, motor-cognitive and executive function performance in African American women.Journal of the neurological sciences · 2022Article
- Mechanistic Insights into Selective Autophagy Subtypes in Alzheimer's Disease.International journal of molecular sciences · 2022Review
- Practical recommendations for timely, accurate diagnosis of symptomatic Alzheimer's disease (MCI and dementia) in primary care: a review and synthesis.Journal of internal medicine · 2021Review
- Alzheimer's Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia.International journal of molecular sciences · 2021Review
- Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.Neurobiology of aging · 2021Article
- Which Occupation is Highly Associated with Cognitive Impairment? A Gender-Specific Longitudinal Study of Paid and Unpaid Occupations in South Korea.International journal of environmental research and public health · 2020Article
- Differential Risk of Cognitive Impairment across Paid and Unpaid Occupations in the Middle-Age Population: Evidence from the Korean Longitudinal Study of Aging, 2006-2016.International journal of environmental research and public health · 2020Article
- Genetic Factors of Alzheimer's Disease Modulate How Diet is Associated with Long-Term Cognitive Trajectories: A UK Biobank Study.Journal of Alzheimer's disease : JAD · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesIdentification of risk factors for Alzheimer disease (AD) is critical for establishing effective diagnostic and therapeutic strategies. Carrying the ε4 allele of the apolipoprotein E gene (APOE4) and having a family history of the disease are two such factors, with family history risk reflecting additional yet unknown or rarely studied genetic and perhaps nongenetic risks. Our aim was to determine the influence of APOE genotype and family history status on cognitive performance in healthy individuals.
designLongitudinal study.
settingSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles.
participantsSeventy-two cognitively healthy middle-aged and older people (mean age ± SD: 62 ± 9 years). MEASUREMENTS: Neuropsychological examinations at baseline and after 2 years.
resultsSubjects with a family history of AD had lower baseline scores in processing speed, executive functioning, memory encoding, and delayed memory when compared with those without a family history. The family history risk factor did not influence degree of cognitive decline over time. By contrast, baseline cognitive performance did not vary according to APOE4 carrier status. Non-APOE4 carriers showed improved cognitive performance in the memory domains at follow-up, while performance of APOE4 carriers did not change.
conclusionsOur data highlight the unique contributions of each risk factor to cognitive performance in healthy people. Both factors should be modeled in neuropsychological assessments of people at risk for AD.
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