ArticleScience translational medicine2011
The emergence of genome-based drug repositioning.
Article in Science translational medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Discovery of Noncancer Drug Effects on Survival in Electronic Health Records of Patients With Cancer: A New Paradigm for Drug Repurposing.JCO clinical cancer informatics · 2019Pooled it
- DrugReX: an explainable drug repurposing system powered by large language models and literature-based knowledge graph.Research square · 2025Article
- Therapeutic Controlled Release Strategies for Human Osteoarthritis.Advanced healthcare materials · 2025Review
- Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data.Cell genomics · 2024Article
- Integrated Computational Approaches for Drug Design Targeting Cruzipain.International journal of molecular sciences · 2024Article
- In-Silico Identification of Novel Pharmacological Synergisms: The Trabectedin Case.International journal of molecular sciences · 2024Article
- Genomic variants-driven drug repurposing for tuberculosis by utilizing the established bioinformatic-based approach.Biochemistry and biophysics reports · 2022Article
- Host-directed therapy, an untapped opportunity for antimalarial intervention.Cell reports. Medicine · 2021Review
- Article
- An Early Stage Researcher's Primer on Systems Medicine Terminology.Network and systems medicine · 2021Review
- Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action.PloS one · 2021Article
- Integrative analysis of clinical and bioinformatics databases to identify anticancer properties of digoxin.Scientific reports · 2019Article
- Repurposing of Drugs as Novel Influenza Inhibitors From Clinical Gene Expression Infection Signatures.Frontiers in immunology · 2019Article
- The Omics Revolution Continues: The Maturation of High-Throughput Biological Data Sources.Yearbook of medical informatics · 2018Review
- Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.Oncotarget · 2018Article
- An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs.PloS one · 2018Article
- Opportunities for Patient Matching Algorithms to Improve Patient Care in Oncology.JCO clinical cancer informatics · 2017Article
- Drug repositioning for enzyme modulator based on human metabolite-likeness.BMC bioinformatics · 2017Article
- Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures.PloS one · 2016Article
- DISCOVERY OF MOLECULARLY TARGETED THERAPIES.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In a pair of papers in this issue of Science Translational Medicine, Butte et al. provide a concrete example of how reinterpreting and comparing genome-wide metrics allows us to effectively hypothesize which drugs from one disease-indication can be repurposed for another disease. The shift toward integrative genome-wide computational approaches has precedence in insightful scalar theories of biological information. Here, we discuss how this recent work in drug repurposing adheres to and takes advantage of the concepts surrounding this information paradigm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.