ArticleJournal of neurophysiology2011
Strain differences in the neural, behavioral, and molecular correlates of sweet and salty taste in naive, ethanol- and sucrose-exposed P and NP rats.
Article in Journal of neurophysiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Kokumi Taste Active Peptides Modulate Salt and Umami Taste.Nutrients · 2020Article
- Chronic exposure to liquid sucrose and dry sucrose diet have differential effects on peripheral taste responses in female rats.Appetite · 2020Article
- Binge-Like, Naloxone-Sensitive, Voluntary Ethanol Intake at Adolescence Is Greater Than at Adulthood, but Does Not Exacerbate Subsequent Two-Bottle Choice Drinking.Frontiers in behavioral neuroscience · 2020Article
- Brief Exposures to the Taste of Ethanol (EtOH) and Quinine Promote Subsequent Acceptance of EtOH in a Paradigm that Minimizes Postingestive Consequences.Alcoholism, clinical and experimental research · 2018Article
- Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs).PloS one · 2018Article
- Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components.Journal of neurophysiology · 2017Article
- Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats.PloS one · 2017Article
- A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.International review of neurobiology · 2016Review
- Nicotinic Acetylcholine Receptor (nAChR) Dependent Chorda Tympani Taste Nerve Responses to Nicotine, Ethanol and Acetylcholine.PloS one · 2015Article
- Effect of ENaC modulators on rat neural responses to NaCl.PloS one · 2014Article
- Experience with sugar modifies behavioral but not taste-evoked medullary responses to sweeteners in mice.Chemical senses · 2013Article
- Sweet preference modified by early experience in mice and the related molecular modulations on the peripheral pathway.Journal of molecular neuroscience : MN · 2013Article
- TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.American journal of physiology. Gastrointestinal and liver physiology · 2013Article
- A/J and C57BL/6J mice differ in chorda tympani responses to NaCl.Neuroscience research · 2013Article
- N-geranyl cyclopropyl-carboximide modulates salty and umami taste in humans and animal models.Journal of neurophysiology · 2013Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to bitter, sweet, and umami taste stimuli.Journal of neurophysiology · 2012Article
- Changes in taste receptor cell [Ca2+]i modulate chorda tympani responses to salty and sour taste stimuli.Journal of neurophysiology · 2012Article
- Oral Nicotine Self-Administration in Rodents.Journal of addiction research & therapy · 2012Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Strain differences between naive, sucrose- and ethanol-exposed alcohol-preferring (P) and alcohol-nonpreferring (NP) rats were investigated in their consumption of ethanol, sucrose, and NaCl; chorda tympani (CT) nerve responses to sweet and salty stimuli; and gene expression in the anterior tongue of T1R3 and TRPV1/TRPV1t. Preference for 5% ethanol and 10% sucrose, CT responses to sweet stimuli, and T1R3 expression were greater in naive P rats than NP rats. The enhancement of the CT response to 0.5 M sucrose in the presence of varying ethanol concentrations (0.5-40%) in naive P rats was higher and shifted to lower ethanol concentrations than NP rats. Chronic ingestion of 5% sucrose or 5% ethanol decreased T1R3 mRNA in NP and P rats. Naive P rats also demonstrated bigger CT responses to NaCl+benzamil and greater TRPV1/TRPV1t expression. TRPV1t agonists produced biphasic effects on NaCl+benzamil CT responses, enhancing the response at low concentrations and inhibiting it at high concentrations. The concentration of a TRPV1/TRPV1t agonist (Maillard reacted peptides conjugated with galacturonic acid) that produced a maximum enhancement in the NaCl+benzamil CT response induced a decrease in NaCl intake and preference in P rats. In naive P rats and NP rats exposed to 5% ethanol in a no-choice paradigm, the biphasic TRPV1t agonist vs. NaCl+benzamil CT response profiles were higher and shifted to lower agonist concentrations than in naive NP rats. TRPV1/TRPV1t mRNA expression increased in NP rats but not in P rats exposed to 5% ethanol in a no-choice paradigm. We conclude that P and NP rats differ in T1R3 and TRPV1/TRPV1t expression and neural and behavioral responses to sweet and salty stimuli and to chronic sucrose and ethanol exposure.
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