ArticleThe Journal of clinical endocrinology and metabolism2011
Treatment of pediatric Graves' disease is associated with excessive weight gain.
Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06921304 (BASE-DIET), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BASE-DIET: a Randomized Clinical Trial to Examine the Impact of a Dietary-nutritional Intervention on Body Weight Recovery, Metabolic Parameters, and Body Composition in Patients With a New Diagnosis of Graves' Disease
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- 2022 European Thyroid Association Guideline for the management of pediatric Graves' disease.European thyroid journal · 2022Guideline
- Initial response of young people with thyrotoxicosis to block and replace or dose titration thionamide.European thyroid journal · 2022Article
- How to use thionamide anti-thyroid drug in the young- what's new?Thyroid research · 2021Review
- Basedow-Graves' disease in a pediatric patient with Sticlker syndrome, a new endocrine finding to improve personalized treatment.Italian journal of pediatrics · 2020Article
- Change in BMI after radioactive iodine ablation for graves disease.International journal of pediatric endocrinology · 2017Article
- Pediatric Graves' disease: management in the post-propylthiouracil Era.International journal of pediatric endocrinology · 2014Review
- Thyroid function and obesity.European thyroid journal · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
contextLittle information is available about changes in body weight and body mass index in children before, during, and after treatment for Graves' disease (GD).
objectiveOur objective was to examine changes in body weight after treatment for GD in children as related to clinical features.
designThe medical records of 43 pediatric patients with GD [35 girls and eight boys, aged 4.0-18.5 (mean 10.9) yr] were examined. Patients were included if clinical data were available for 1 yr before and after the diagnosis of GD.
main outcome measuresWeight, height, body mass index (BMI) z-scores, and thyroid hormone levels were assessed.
resultsOverall, patients presented with an average BMI z-score of -0.02 ± 1.05 that was not different from the normal population (P = 0.921) or their premorbid values (P = 0.07). However, in the subset of patients who were initially overweight or obese in the premorbid state, the BMI decreased significantly during the development of hyperthyroidism (P < 0.05). After initiation of treatment, patients gained significant amounts of weight over the first 6 months leading to elevated BMI z-scores (P < 0.0001), and elevations in BMI persisted in about 25% of the patients.
conclusionExcessive weight gain within 6 months of treatment is seen in children treated for GD, and the gain in weight can persist.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.