ArticleThe Journal of biological chemistry2011
Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivation.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- In thePNAS nexus · 2026Article
- Genome-wide screen reveals dependence of break induced replication on several distinct checkpoints.Nature communications · 2025Article
- Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions.Cellular & molecular biology letters · 2024Review
- Cla4 phosphorylates histone methyltransferase Set1 to prevent its degradation by the APC/CScience advances · 2023Article
- H3 Lysine 4 Methylation Is Required for Full Activation of Genes Involved in α-Ketoglutarate Availability in the Nucleus of Yeast Cells after Diauxic Shift.Metabolites · 2023Article
- H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants.Planta · 2021Review
- The past determines the future: sugar source history and transcriptional memory.Current genetics · 2020Review
- Metabolic transcriptional memory.Molecular metabolism · 2020Review
- Epigenetic memory in gene regulation and immune response.BMB reports · 2019Review
- Rpd3L HDAC links H3K4me3 to transcriptional repression memory.Nucleic acids research · 2018Article
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- Yeast Replicator: A High-Throughput Multiplexed Microfluidics Platform for Automated Measurements of Single-Cell Aging.Cell reports · 2015Article
- Chromatin dynamics: H3K4 methylation and H3 variant replacement during development and in cancer.Cellular and molecular life sciences : CMLS · 2014Review
- Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.Molecular oncology · 2014Article
- Divergence and selectivity of expression-coupled histone modifications in budding yeasts.PloS one · 2014Article
- An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors.PloS one · 2014Article
- Dynamics of yeast histone H2A and H2B phosphorylation in response to a double-strand break.Nature structural & molecular biology · 2014Article
- Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation.The Biochemical journal · 2013Article
- Making sense of transcribing chromatin.Current opinion in cell biology · 2012Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent transcription of GAL genes transiently leaves an H3K4 methylation mark at their promoters, providing an epigenetic memory for the recent transcriptional activity. However, the physiological significance of this mark is enigmatic. In our study, we show that the transient H3K4 di- and trimethylation at recently transcribed GAL1 inhibited the reinduction of GAL1. The H3K4 methylation functioned by recruiting the Isw1 ATPase onto GAL1 and thereby limiting the action of RNA polymerase II during GAL1 reactivation. Strikingly, the H3K4 methylation was also observed at the promoters of inositol- and fatty acid-responsive genes after recent transcription and played a negative role in their reinduction. Taken together, our data present a new mechanism by which H3K4 methylation regulates gene transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.