ArticleJournal of virology2011
Comparative analysis of avian influenza virus diversity in poultry and humans during a highly pathogenic avian influenza A (H7N7) virus outbreak.
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Assessing Evidence to Guide Primary Prevention of Pathogen X.Emerging infectious diseases · 2026Article
- Avian influenza in birds: Insights from a comprehensive review.Veterinary world · 2024Review
- Comparison of the Clinical Manifestation of HPAI H5Nx in Different Poultry Types in the Netherlands, 2014-2022.Pathogens (Basel, Switzerland) · 2024Article
- Amino acid sites related to the PB2 subunits of IDV affect polymerase activity.Virology journal · 2021Article
- An Outbreak of Highly Pathogenic Avian Influenza (H7N7) in Australia and the Potential for Novel Influenza A Viruses to Emerge.Microorganisms · 2021Review
- Host Receptors of Influenza Viruses and Coronaviruses-Molecular Mechanisms of Recognition.Vaccines · 2020Review
- Zoonotic Influenza and Human Health-Part 1: Virology and Epidemiology of Zoonotic Influenzas.Current infectious disease reports · 2018Review
- Evaluation of the Immune Responses to and Cross-Protective Efficacy of Eurasian H7 Avian Influenza Viruses.Journal of virology · 2017Article
- Antigenic Fingerprinting of Antibody Response in Humans following Exposure to Highly Pathogenic H7N7 Avian Influenza Virus: Evidence for Anti-PA-X Antibodies.Journal of virology · 2016Article
- Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.EcoHealth · 2016Review
- Epidemic Reconstruction in a Phylogenetics Framework: Transmission Trees as Partitions of the Node Set.PLoS computational biology · 2015Article
- Less is more: an adaptive branch-site random effects model for efficient detection of episodic diversifying selection.Molecular biology and evolution · 2015Article
- Wind-Mediated Spread of Low-Pathogenic Avian Influenza Virus into the Environment during Outbreaks at Commercial Poultry Farms.PloS one · 2015Article
- Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong.The Journal of infection · 2014Article
- Avian influenza A viruses: from zoonosis to pandemic.Future virology · 2014Article
- Human antibody responses to avian influenza A(H7N9) virus, 2013.Emerging infectious diseases · 2014Article
- Emergence of the virulence-associated PB2 E627K substitution in a fatal human case of highly pathogenic avian influenza virus A(H7N7) infection as determined by Illumina ultra-deep sequencing.Journal of virology · 2014Article
- Mammalian models for the study of H7 virus pathogenesis and transmission.Current topics in microbiology and immunology · 2014Review
- Interspecies transmission and emergence of novel viruses: lessons from bats and birds.Trends in microbiology · 2013Review
- Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Although increasing data have become available that link human adaptation with specific molecular changes in nonhuman influenza viruses, the molecular changes of these viruses during a large highly pathogenic avian influenza virus (HPAI) outbreak in poultry along with avian-to-human transmission have never been documented. By comprehensive virologic analysis of combined veterinary and human samples obtained during a large HPAI A (H7N7) outbreak in the Netherlands in 2003, we mapped the acquisition of human adaptation markers to identify the public health risk associated with an HPAI outbreak in poultry. Full-length hemagglutinin (HA), neuraminidase (NA), and PB2 sequencing of A (H7N7) viruses obtained from 45 human cases showed amino acid variations at different codons in HA (n=20), NA (n=23), and PB2 (n=23). Identification of the avian sources of human virus infections based on 232 farm sequences demonstrated that for each gene about 50% of the variation was already present in poultry. Polygenic accumulation and farm-to-farm spread of known virulence and human adaptation markers in A (H7N7) virus-infected poultry occurred prior to farm-to-human transmission. These include the independent emergence of HA A143T mutants, accumulation of four NA mutations, and farm-to-farm spread of virus variants harboring mammalian host determinants D701N and S714I in PB2. This implies that HPAI viruses with pandemic potential can emerge directly from poultry. Since the public health risk of an avian influenza virus outbreak in poultry can rapidly change, we recommend virologic monitoring for human adaptation markers among poultry as well as among humans during the course of an outbreak in poultry.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.