Evidence map›Paper›PMID 21849309›Full record

ArticleBiology letters2012

Selection on codon usage and base composition in Drosophila americana.

Sophie Marion de Procé, Kai Zeng, Andrea J Betancourt, Brian Charlesworth

Abstract readComparative Study
In one paragraph

Article in Biology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sophie Marion de ProcéInstitute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. sdeproce@staffmail.ed.ac.uk
Kai Zeng
Andrea J Betancourt
Brian Charlesworth

Funding

Biotechnology and Biological Sciences Research Council BB/G003076/1
6 · The paper itself

Abstract

We have used a polymorphism dataset on introns and coding sequences of X-linked loci in Drosophila americana to estimate the strength of selection on codon usage and/or biased gene conversion (BGC), taking into account a recent population expansion detected by a maximum-likelihood method. Drosophila americana was previously thought to have a stable demographic history, so that this evidence for a recent population expansion means that previous estimates of selection need revision. There was evidence for natural selection or BGC favouring GC over AT variants in introns, which is stronger for GC-rich than GC-poor introns. By comparing introns and coding sequences, we found evidence for selection on codon usage bias, which is much stronger than the forces acting on GC versus AT basepairs in introns.

Indexed as

AnimalsBase CompositionBase SequenceCodonDrosophilaLikelihood FunctionsMaleMissouriMolecular Sequence DataPopulation DynamicsSelection, GeneticSequence AlignmentSequence Analysis, DNACodon

Identifiers

PMID21849309
PMCPMC3259966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.