Evidence map›Paper›PMID 21848436›Full record

ReviewStress (Amsterdam, Netherlands)2011

Stress risk factors and stress-related pathology: neuroplasticity, epigenetics and endophenotypes.

Jason J Radley, Mohamed Kabbaj, Lauren Jacobson, Willem Heydendael, Rachel Yehuda, James P Herman

Open access · greenAbstract readReview
In one paragraph

Review in Stress (Amsterdam, Netherlands), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
  2. Review
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  7. Observational
  8. Article
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  11. Review
  12. The Relationship between Allostasis and Mental Health Patterns in a Pre-Deployment French Military Cohort.European journal of investigation in health, psychology and education · 2021
    Article
  13. Article
  14. Article
  15. Cortisol AuPd plasmonic unclad POF biosensor.Biotechnology reports (Amsterdam, Netherlands) · 2021
    Article
  16. Stress and Cardiometabolic Disease Risk for Indigenous Populations throughout the Lifespan.International journal of environmental research and public health · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 1 country.

Jason J RadleyDepartment of Psychology, University of Iowa, Iowa City, IA, USA.
Mohamed Kabbaj
Lauren Jacobson
Willem Heydendael
Rachel Yehuda
James P Herman
Albany Medical Center Hospital · USFlorida State University · USIcahn School of Medicine at Mount Sinai · USUniversity of Cincinnati · USUniversity of Iowa · US

Funding

FUNCTIONAL ANATOMY OF LIMBIC NEUROENDOCRINE CIRCUITSR01MH049698 · NIMH · UNIVERSITY OF KENTUCKY · PI HERMAN, JAMES P · 1998 to 2018
$6.2M
Brainstem Mechanisms of Stress RegulationR01MH069860 · NIMH · UNIVERSITY OF CINCINNATI · PI HERMAN, JAMES P · 2004 to 2014
$3.5M
Sex Differences In Anxiety: Role of Zif268R01MH087583 · NIMH · FLORIDA STATE UNIVERSITY · PI KABBAJ, MOHAMED · 2010 to 2014
$1.8M
Identification of an Epigenetic Risk Marker for PTSDRC1MH088101 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YEHUDA, RACHEL · 2009 to 2010
$1000k
Glucocorticoid & corticosteriod receptor-dependence of HPA activity and behaviorR01MH080394 · NIMH · ALBANY MEDICAL COLLEGE · PI JACOBSON, LAUREN · 2008 to 2011
$987k
Epigenetics of Social BondingR21MH083128 · NIMH · FLORIDA STATE UNIVERSITY · PI KABBAJ, MOHAMED, WANG, ZUOXIN · 2010 to 2011
$402k
Epigenetics of Social DefeatR21MH081046 · NIMH · FLORIDA STATE UNIVERSITY · PI KABBAJ, MOHAMED · 2009 to 2010
$398k
Neurobiology of Stress Workshop 2010R13MH090623 · NIMH · UNIVERSITY OF COLORADO · PI HERMAN, JAMES P, KOENIG, JAMES I · 2010 to 2010
$19k
NIMH NIH HHS R01 MH049698NIMH NIH HHS R01 MH069860NIMH NIH HHS R01 MH080394NIMH NIH HHS R01MH080394NIMH NIH HHS R01 MH087583NIMH NIH HHS R01MH087583NIMH NIH HHS R13 MH090623NIMH NIH HHS R13MH090623NIMH NIH HHS R21 MH081046NIMH NIH HHS R21MH081046NIMH NIH HHS R21 MH083128NIMH NIH HHS R21MH083128NIMH NIH HHS RC1MH08810NIMH NIH HHS RC1 MH088101
6 · The paper itself

Abstract

This paper highlights a symposium on stress risk factors and stress susceptibility, presented at the Neurobiology of Stress workshop in Boulder, CO, in June 2010. This symposium addressed factors linking stress plasticity and reactivity to stress pathology in animal models and in humans. Dr. J. Radley discussed studies demonstrating prefrontal cortical neuroplasticity and prefrontal control of hypothalamo-pituitary-adrenocortical axis function in rats, highlighting the emerging evidence of the critical role that this region plays in normal and pathological stress integration. Dr. M. Kabbaj summarized his studies of possible epigenetic mechanisms underlying behavioral differences in rat populations bred for differential stress reactivity. Dr. L. Jacobson described studies using a mouse model to explore the diverse actions of antidepressants in brain, suggesting mechanisms whereby antidepressants may be differentially effective in treating specific depression endophenotypes. Dr. R. Yehuda discussed the role of glucocorticoids in post-traumatic stress disorder (PTSD), indicating that low cortisol level may be a trait that predisposes the individual to development of the disorder. Furthermore, she presented evidence indicating that traumatic events can have transgenerational impact on cortisol reactivity and development of PTSD symptoms. Together, the symposium highlighted emerging themes regarding the role of brain reorganization, individual differences, and epigenetics in determining stress plasticity and pathology.

Indexed as

EndophenotypesEpigenesis, GeneticNeuronal PlasticityAnimalsAntidepressive AgentsHippocampusHumansHydrocortisoneHypothalamo-Hypophyseal SystemLimbic SystemMicePituitary-Adrenal SystemRatsReceptors, GlucocorticoidSocial DominanceStress Disorders, Post-TraumaticAntidepressive AgentsHydrocortisoneReceptors, Glucocorticoid

Identifiers

PMID21848436
PMCPMC3641164
OpenAlexW2144879545

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.