Trial reportStroke2011
Response to psychosocial treatment in poststroke depression is associated with serotonin transporter polymorphisms.
Trial report in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00194454 (Psychosocial/Behavioral Intervention in PSD), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Psychosocial/Behavioral Intervention in PSD
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Pharmacological, non-invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke.The Cochrane database of systematic reviews · 2023Pooled it
- Efficacy of repetitive transcranial magnetic stimulation for post-stroke depression: a systematic review and meta-analysis of randomized clinical trials.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Pooled it
- Pharmacological, psychological, and non-invasive brain stimulation interventions for treating depression after stroke.The Cochrane database of systematic reviews · 2020Pooled it
- Length Polymorphisms in the Angiotensin I-Converting Enzyme Gene and the Serotonin-Transporter-Linked Polymorphic Region Constitute a Risk Haplotype for Depression in Patients with Coronary Artery Disease.Biochemical genetics · 2020Trial
- Trial
- Trial
- Non-replication of the association between 5HTTLPR and response to psychological therapy for child anxiety disorders.The British journal of psychiatry : the journal of mental science · 2016Trial
- Response rate profiles for major depressive disorder: Characterizing early response and longitudinal nonresponse.Depression and anxiety · 2018Article
- Observational
- Vantage sensitivity: a framework for individual differences in response to psychological intervention.Social psychiatry and psychiatric epidemiology · 2018Review
- Treatments to Promote Neural Repair after Stroke.Journal of stroke · 2018Review
- Psychotherapy and Genetic Neuroscience: An Emerging Dialog.Frontiers in genetics · 2018Review
- Rare Variants of the Serotonin Transporter Are Associated With Psychiatric Comorbidity in Irritable Bowel Syndrome.Biological research for nursing · 2016Article
- Genetics as a molecular window into recovery, its treatment, and stress responses after stroke.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2016Review
- A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.Psychotherapy and psychosomatics · 2016Article
- Drugs to Enhance Motor Recovery After Stroke.Stroke · 2015Review
- Therapygenetics: Using genetic markers to predict response to psychological treatment for mood and anxiety disorders.Biology of mood & anxiety disorders · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe Living Well With Stroke study has demonstrated effectiveness of a brief psychosocial treatment in reducing depressive symptoms after stroke. The purpose of this analysis was to determine whether key variables associated with prevalence of poststroke depression also predicted treatment response.
methodsResponse to a brief psychosocial/behavioral intervention for poststroke depression was measured with the Hamilton Rating Scale for Depression. Analysis of covariance models tested for interaction of potential predictor variables with treatment group on percent change in Hamilton Rating Scale for Depression from pre- to post-treatment as an outcome.
resultsInitial depression severity, hemispheric location, level of social support, age, gender, and antidepressant adherence did not interact with the treatment with respect to percent change in Hamilton Rating Scale for Depression when considered 1 at a time. Participants who carried 1 or 2 s-alleles at the 5-HTTLPR serotonin transporterpolymorphism or 1 or 2 9- or 12-repeats of the STin2 VNTR polymorphism had significantly better response to psychosocial treatment than those with no s-alleles or no 9- or 12-repeats.
conclusionsOpposite to the effects of antidepressant drug treatment with selective serotonin reuptake inhibitors, the Living Well With Stroke psychotherapy intervention was most effective in 5-HTTLPR s-allele carriers and STin2VNTR 9- or 12-repeat carriers. CLINICAL
trial registrationURL: www.clinicaltrials.gov/ct/show/NCT00194454?order_1. Unique identifier: NCT00194454.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.