ArticleSurgical endoscopy2012
Transgastric endoscopic pneumoperitoneum versus laparoscopy: effects on host systemic and peritoneal inflammatory responses in a porcine model.
Article in Surgical endoscopy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Accurate and Rapid Detection of Peritoneal Metastasis from Gastric Cancer by AI-Assisted Stimulated Raman Molecular Cytology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Comparison of Inflammatory Response to Transgastric and Transcolonic NOTES.Gastroenterology research and practice · 2016Article
- Acute inflammatory response to transgastric natural orifice transluminal endoscopic surgery peritoneoscopy: an experimental study in swine.Clinics (Sao Paulo, Brazil) · 2013Article
- The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction.JSLS : Journal of the Society of Laparoendoscopic SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe host systemic and peritoneal immune responses during natural orifice transluminal endoscopic surgery (NOTES) continues to be delineated. The immune response to laparoscopy (LAP) has been favorably depicted. However, the immunologic effects of NOTES are yet to be determined, and the introduction of contaminants via the host orificium may have deleterious effects. The purpose of this study was to characterize the effect that NOTES would have on porcine systemic and peritoneal immune function.
methodsTwenty-four pigs were divided into three groups: ENDO (upper-endoscopy control), NOTES, and LAP. All animals had blood and peritoneal lavage samples collected for cytokine analysis pre- and postoperatively. Interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor α (TNFα), and interferon γ (IFNγ) levels were quantified using enzyme-linked immunosorbent assay (ELISA). Peritoneal lavage samples were cultured and identified by group and time of collection for microbiological analysis.
resultsTNFα was found in detectable levels in serum samples of all three groups. For the NOTES group, there was a significant increase in TNFα at t = 1 h (P < 0.01), which dropped significantly at t = 48 h (P < 0.01). IL-1β was present as an early response in NOTES lavage samples (t = 0 and t = 1 h). Both LAP and NOTES had similar elevation of IL-1β in the final lavage samples at t = 48 h. The other cytokines were not consistently found above detectable levels in any group. Similar microbiological contaminants were found in the ENDO and LAP groups. In the NOTES group, no significant growth was observed from cultures at 48 h.
conclusionsFor measurable cytokines, the NOTES inflammatory response was not significantly different from that of the LAP group. NOTES did not carry a significantly increased amount of microbiological contamination at 48 h compared to LAP. These data suggest that the host immune response to NOTES does not significantly differ from that to LAP in a porcine model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.