ArticleWorld journal of urology2011
Novel contrast-enhanced ultrasound imaging in prostate cancer.
Article in World journal of urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Multiparametric ultrasound in the detection of prostate cancer: a systematic review.World journal of urology · 2015Pooled it
- Contrast-enhanced ultrasonography in differential diagnosis of benign and malignant ovarian tumors.PloS one · 2015Pooled it
- Focal vs extended ablation in localized prostate cancer with irreversible electroporation; a multi-center randomized controlled trial.BMC cancer · 2016Trial
- Usefulness of perflubutane microbubble-enhanced ultrasound in imaging and detection of prostate cancer: phase II multicenter clinical trial.World journal of urology · 2013Trial
- Radiomics-Based Characterization of Aggressive Prostate Cancer Variants: Diagnostic Challenges and Opportunities.Cancers · 2026Review
- Clinical Utility of Contrast-Enhanced Ultrasound (CEUS) in Urology: A Multisystem Review.Cureus · 2025Review
- Dynamic Contrast-Enhanced Ultrasound Modeling of an Analog to Pseudo-Diffusivity in Intravoxel Incoherent Motion Magnetic Resonance Imaging.IEEE transactions on medical imaging · 2022Article
- Registration of trans-perineal template mapping biopsy cores to volumetric ultrasound.International journal of computer assisted radiology and surgery · 2022Article
- Irreversible Electroporation for the Ablation of Prostate Cancer.Current urology reports · 2019Review
- Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy.Theranostics · 2018Article
- A human GRPr-transfected Ace-1 canine prostate cancer model in mice.The Prostate · 2016Article
- [Prostate biopsy: Procedure in the clinical routine].Der Urologe. Ausg. A · 2015Review
- Optical Verification of Microbubble Response to Acoustic Radiation Force in Large Vessels With In Vivo Results.Investigative radiology · 2015Article
- Prostate cancer: a comparison of the diagnostic performance of transrectal ultrasound versus contrast enhanced transrectal ultrasound in different clinical characteristics.International journal of clinical and experimental medicine · 2015Article
- The future perspectives in transrectal prostate ultrasound guided biopsy.Prostate international · 2014Review
- Article
- [Imaging of the prostate].Der Urologe. Ausg. A · 2013Article
- Office ultrasound for the urologist.Current urology reports · 2012Article
- Prostate focused ultrasound focal therapy--imaging for the future.Nature reviews. Clinical oncology · 2012Review
- Applications of transrectal ultrasound in prostate cancer.The British journal of radiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purposes of this paper were to present the current status of contrast-enhanced transrectal ultrasound imaging and to discuss the latest achievements and techniques now under preclinical testing.
objectiveAlthough grayscale transrectal ultrasound is the standard method for prostate imaging, it lacks accuracy in the detection and localization of prostate cancer. With the introduction of contrast-enhanced ultrasound (CEUS), perfusion imaging of the microvascularization became available. By this, cancer-induced neovascularisation can be visualized with the potential to improve ultrasound imaging for prostate cancer detection and localization significantly. For example, several studies have shown that CEUS-guided biopsies have the same or higher PCa detection rate compared with systematic biopsies with less biopsies needed. MATERIALS AND
methodsThis paper describes the current status of CEUS and discusses novel quantification techniques that can improve the accuracy even further. Furthermore, quantification might decrease the user-dependency, opening the door to use in the routine clinical environment. A new generation of targeted microbubbles is now under pre-clinical testing and showed avidly binding to VEGFR-2, a receptor up-regulated in prostate cancer due to angiogenesis. The first publications regarding a targeted microbubble ready for human use will be discussed.
conclusionUltrasound-assisted drug delivery gives rise to a whole new set of therapeutic options, also for prostate cancer. A major breakthrough in the future can be expected from the clinical use of targeted microbubbles for drug delivery for prostate cancer diagnosis as well as treatment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.