ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2011
Reactive astrocytosis in feline neonatal hydrocephalus: acute, chronic, and shunt-induced changes.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Exploring and translating novel approaches targeting the choroid plexus for the treatment of hydrocephalus: a literature review.Fluids and barriers of the CNS · 2026Review
- Impaired neurogenesis with reactive astrocytosis in the hippocampus in a porcine model of acquired hydrocephalus.Experimental neurology · 2023Article
- Acquired hydrocephalus is associated with neuroinflammation, progenitor loss, and cellular changes in the subventricular zone and periventricular white matter.Fluids and barriers of the CNS · 2022Article
- Novel therapeutic modulators of astrocytes for hydrocephalus.Frontiers in molecular neuroscience · 2022Review
- A novel model of acquired hydrocephalus for evaluation of neurosurgical treatments.Fluids and barriers of the CNS · 2021Article
- Lipid Peroxidation Induces Reactive Astrogliosis by Activating WNT/β-Catenin Pathway in Hydrocephalus.The Malaysian journal of medical sciences : MJMS · 2020Article
- Erythropoietin protects the subventricular zone and inhibits reactive astrogliosis in kaolin-induced hydrocephalic rats.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Article
- Effects of Melatonin on the Cerebellum of Infant Rat Following Kaolin-Induced Hydrocephalus: a Histochemical and Immunohistochemical Study.Cerebellum (London, England) · 2017Article
- Article
- Abnormal Injury Response in Spontaneous Mild Ventriculomegaly Wistar Rat Brains: A Pathological Correlation Study of Diffusion Tensor and Magnetization Transfer Imaging in Mild Traumatic Brain Injury.Journal of neurotrauma · 2017Article
- Diffusion tensor imaging with direct cytopathological validation: characterisation of decorin treatment in experimental juvenile communicating hydrocephalus.Fluids and barriers of the CNS · 2016Article
- Imaging of spontaneous ventriculomegaly and vascular malformations in Wistar rats: implications for preclinical research.Journal of neuropathology and experimental neurology · 2014Article
- Long-term hydrocephalus alters the cytoarchitecture of the adult subventricular zone.Experimental neurology · 2014Article
- Differential vulnerability of white matter structures to experimental infantile hydrocephalus detected by diffusion tensor imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: inflammatory cytokines.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2014Article
- Kaolin-induced ventriculomegaly at weaning produces long-term learning, memory, and motor deficits in rats.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2014Article
- High resolution MRI anatomy of the cat brain at 3 Tesla.Journal of neuroscience methods · 2014Article
- Structure and function of the ependymal barrier and diseases associated with ependyma disruption.Tissue barriers · 2014Review
- Fingerprint changes in CSF composition associated with different aetiologies in human neonatal hydrocephalus: glial proteins associated with cell damage and loss.Fluids and barriers of the CNS · 2013Article
- Decorin prevents the development of juvenile communicating hydrocephalus.Brain : a journal of neurology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeReactive astrocytosis has been implicated in injury and recovery patterns associated with hydrocephalus. To investigate temporal changes in astrogliosis during the early progression of hydrocephalus, after shunting, and after long-term ventriculomegaly, glial fibrillary protein (GFAP) levels were analyzed in a feline model.
methodsObstructive hydrocephalus was induced in 10-day-old kittens by intracisternal injections of 25% kaolin. Acute non-shunted animals were killed 15 days post-kaolin injection to represent the pre-shunt condition. Shunt-treated animals received ventriculoperitoneal shunts 15 days post-injection and were killed 10 or 60 days later to represent short- and long-term recovery periods. Chronic untreated animals had Ommaya reservoirs implanted 15 days post-kaolin, which were tapped intermittently until they were killed 60 days later. Ventriculomegaly was monitored by neuroimaging before and after shunting and at death. RNA and total protein from primary visual cortex were analyzed by Northern and Western blotting.
resultsGFAP RNA and protein levels for acute and chronic non-shunted hydrocephalic animals were 77% and 247% (p < 0.01) and 659% (p < 0.05) and 871% (p < 0.05) higher than controls, respectively. Shunted animals with short-term recovery demonstrated a mismatch in GFAP levels, with RNA expression decreasing 26% and protein increasing 335% (p < 0.01). Shunted animals with a long-term recovery exhibited GFAP RNA and protein levels 201% and 357% above normal, respectively.
conclusionsThese results indicate that a reactive astrocytic response continues to rise dramatically in chronic hydrocephalus, suggesting ongoing gliosis and potential damage. Shunting partially ameliorates the continuation of astrogliosis, but does not completely reverse this inflammatory reaction even after a long recovery.
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