ArticleParasitology research2012
Antiplasmodial activity of Xanthium strumarium against Plasmodium berghei-infected BALB/c mice.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Antioxidant and Anti-Inflammatory Effects of Traditional Medicinal Plants for Urolithiasis: A Scoping Review.Plants (Basel, Switzerland) · 2025Review
- Phytochemical analysis and antioxidant, antimicrobial, and cytotoxic activities ofTurkish journal of biology = Turk biyoloji dergisi · 2025Article
- Sesquiterpene lactones-enriched fractions fromFrontiers in pharmacology · 2023Article
- Guaianolide Derivatives from the InvasiveMolecules (Basel, Switzerland) · 2022Article
- Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities.BMC complementary medicine and therapies · 2022Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Pharmacological Potential of Small Molecules for Treating Corneal Neovascularization.Molecules (Basel, Switzerland) · 2020Review
- Mining Sudanese Medicinal Plants for Antiprotozoal Agents.Frontiers in pharmacology · 2020Article
- Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2‑mediated STAT3/PI3K/Akt signaling pathway.International journal of molecular medicine · 2018Article
- Antimalarial efficacy of Albizia lebbeck (Leguminosae) against Plasmodium falciparum in vitro & P. berghei in vivo.The Indian journal of medical research · 2015Article
- Article
- In vivo antimalarial evaluation of MAMA decoction on Plasmodium berghei in mice.Parasitology research · 2014Article
- Antiplasmodial activity of ethanolic extracts of some selected medicinal plants from the northwest of Iran.Parasitology research · 2013Article
- Antimalarial activity of Bergenia ciliata (Haw.) Sternb. against Plasmodium berghei.Parasitology research · 2013Article
- Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System.Journal of parasitology research · 2013Article
- Identifying three ecological chemotypes of Xanthium strumarium glandular trichomes using a combined NMR and LC-MS method.PloS one · 2013Article
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3 authors.
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Abstract
The present work was undertaken to evaluate the antiplasmodial activity of ethanolic leaves extract of traditional medicinal plant Xanthium strumarium in Plasmodium berghei-infected BALB/c mice along with phytochemical screening and acute toxicity test to support its traditional medicinal use as a malaria remedy. The ethanolic leaves extract of X. strumarium (ELEXS) 150, 250, 350 and 500 mg/kg/day demonstrated dose-dependent chemosuppression during early and established infection long with significant (p < 0.001) repository activity. The oral administration of 500 mg/kg/day concentration showed a maximum of 88.6% chemosuppression during early infection, which was more than that of the standard drug chloroquine (5 mg/kg/day) with 88.3% chemosuppression. However, 60% mortality has been found in this group. The LD(50) of ELEXS was found to be 1.5 g/kg/mouse. The administration of 350 mg/kg/day concentration of extract have been found to exert 90.40% chemosuppression during repository infection, which was well comparable to standard drug pyrimethamine (1.2 mg/kg/day) exerting 92.91% chemosuppression. The extract has been found to enhance mean survival time of mice from 21 to 26 days with 250 and 350 mg/kg/day concentrations, while 150 mg/kg/day concentration has been found to sustain all the mice up to 29 days which was similar to the employed standard drug chloroquine (5 mg/kg/day). All these findings support the ethanopharmacological use of X. strumarium as malarial remedy and indicate the potential of plant for active antiplasmodial components.
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