Trial reportPsychopharmacology2012
Beta receptor-mediated modulation of the late positive potential in humans.
Trial report in Psychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Learning Experience Reverses Catecholaminergic Effects on Adaptive Behavior.The international journal of neuropsychopharmacology · 2020Trial
- Catecholaminergic Regulation of Learning Rate in a Dynamic Environment.PLoS computational biology · 2016Trial
- Beta receptor-mediated modulation of the oddball P3 but not error-related ERP components in humans.Psychopharmacology · 2015Trial
- Transcutaneous Auricular Vagus Nerve Stimulation Enhances Emotional Processing and Long-Term Recognition Memory: Electrophysiological Evidence Across Two Studies.Psychophysiology · 2025Article
- Electrophysiological Evidence of Enhanced Processing of Novel Pornographic Images in Individuals With Tendencies Toward Problematic Internet Pornography Use.Frontiers in human neuroscience · 2022Article
- Influence of Perceptual and Conceptual Information on Fear Generalization: A Behavioral and Event-Related Potential Study.Cognitive, affective & behavioral neuroscience · 2021Article
- In God we trust? Neural measures reveal lower social conformity among non-religious individuals.Social cognitive and affective neuroscience · 2017Article
- Heritability of the neural response to emotional pictures: evidence from ERPs in an adult twin sample.Social cognitive and affective neuroscience · 2015Article
- Blinking predicts enhanced cognitive control.Cognitive, affective & behavioral neuroscience · 2013Article
- Inferior frontal gyrus preserves working memory and emotional learning under conditions of impaired noradrenergic signaling.Frontiers in behavioral neuroscience · 2013Article
- Functional significance of the emotion-related late positive potential.Frontiers in human neuroscience · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleElectrophysiological studies have identified a scalp potential, the late positive potential (LPP), which is modulated by the emotional intensity of observed stimuli. Previous work has shown that the LPP reflects the modulation of activity in extrastriate visual cortical structures, but little is known about the source of that modulation.
objectivesThe present study investigated whether beta-adrenergic receptors are involved in the generation of the LPP.
methodsWe used a genetic individual differences approach (experiment 1) and a pharmacological manipulation (experiment 2) to test the hypothesis that the LPP is modulated by the activation of β-adrenergic receptors.
resultsIn experiment 1, we found that LPP amplitude depends on allelic variation in the β1-receptor gene polymorphism. In experiment 2, we found that LPP amplitude was modulated by the β-blocker propranolol in a direction dependent on subjects' level of trait anxiety: In participants with lower trait anxiety, propranolol led to a (nonsignificant) decrease in the LPP modulation; in participants with higher trait anxiety, propranolol increased the emotion-related LPP modulation.
conclusionsThese results provide initial support for the hypothesis that the LPP reflects the downstream effects, in visual cortical areas, of β-receptor-mediated activation of the amygdala.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.