ReviewCurrent psychiatry reports2011
Use of lithium in the treatment of bipolar disorder in late-life.
Review in Current psychiatry reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Lithium Toxicity in Older Adults: a Systematic Review of Case Reports.Clinical drug investigation · 2018Pooled it
- Lithium Induces Oxidative Stress, Apoptotic Cell Death, and G2/M Phase Cell Cycle Arrest in A549 Lung Cancer Cells.Molecules (Basel, Switzerland) · 2025Article
- Catatonia Due to Lithium Neurotoxicity: A Case Report.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2024Article
- Lithium chloride inhibits early stages of foot-and-mouth disease virus (FMDV) replication in vitro.Journal of medical virology · 2017Article
- Mood disorders in the elderly: prevalence, functional impact, and management challenges.Neuropsychiatric disease and treatment · 2016Review
- Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement.BMC neuroscience · 2015Article
- Current electroconvulsive therapy practice and research in the geriatric population.Neuropsychiatry · 2014Article
- Article
- Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder.Pharmacological reviews · 2013Review
- Prophylaxis and treatment of bipolar disorder in older adults.Journal of psychiatry & neuroscience : JPN · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Lithium is the oldest and still one of the most frequently prescribed mood stabilizers in the treatment of bipolar disorder. Nonetheless, the evidence for lithium efficacy in older patients with bipolar disorder is almost entirely extrapolated from younger adult patients. Here we review the literature on lithium in older patients with bipolar disorder, concentrating on the past 3 years. A definitive study demonstrating the efficacy and safety of lithium in older patients with bipolar disorder is still missing. However, several lines of indirect evidence suggest that it is beneficial and advantageous over other mood stabilizers in the acute and maintenance treatment of late-life bipolar disorder. In addition, lithium may have unique properties as a regenerative therapeutic with specific benefits in reducing the cognitive impairment and suicide rates associated with bipolar disorder across the adult lifespan. Aging-associated pharmacokinetic and pharmacodynamic changes as well as increased rates of medical comorbidities and polypharmacy predispose older patients to a higher risk of lithium toxicity. Careful monitoring and adjustment of lithium dosage is especially important in older adults to minimize the risk of toxicity.
Indexed as
Identifiers
21847537What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.