ArticleThe EMBO journal2011
PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Tyro3 promotes the maturation of glutamatergic synapses.Frontiers in neuroscience · 2024Article
- The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples.Biomedicines · 2023Article
- PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats.International journal of molecular sciences · 2020Article
- Promoter DNA hypermethylation - Implications for Alzheimer's disease.Neuroscience letters · 2019Review
- The role of PI3K-mediated AMPA receptor changes in post-conditioning of propofol in brain protection.BMC neuroscience · 2019Article
- Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.Neuroscience bulletin · 2019Article
- PIPScientific reports · 2019Article
- Mechanisms of AMPA Receptor Endosomal Sorting.Frontiers in molecular neuroscience · 2018Review
- Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.The Journal of biological chemistry · 2015Article
- Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome.Cell reports · 2015Article
- PTEN regulates AMPA receptor-mediated cell viability in iPS-derived motor neurons.Cell death & disease · 2014Article
- PIKE is essential for oligodendroglia development and CNS myelination.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Article
- AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Coupling mechanical forces to electrical signaling: molecular motors and the intracellular transport of ion channels.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2013Review
- Simvastatin induces neuroprotection in 6-OHDA-lesioned PC12 via the PI3K/AKT/caspase 3 pathway and anti-inflammatory responses.CNS neuroscience & therapeutics · 2013Article
- Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer?Reviews in the neurosciences · 2012Review
- Essential role of PIKE GTPases in neuronal protection against excitotoxic insults.Advances in biological regulation · 2012Article
- Long-lasting LTP requires neither repeated trains for its induction nor protein synthesis for its development.PloS one · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
AMPAR (α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor) is an ion channel involved in the formation of synaptic plasticity. However, the molecular mechanism that couples plasticity stimuli to the trafficking of postsynaptic AMPAR remains poorly understood. Here, we show that PIKE (phosphoinositide 3-kinase enhancer) GTPases regulate neuronal AMPAR activity by promoting GluA2/GRIP1 association. PIKE-L directly interacts with both GluA2 and GRIP1 and forms a tertiary complex upon glycine-induced NMDA receptor activation. PIKE-L is also essential for glycine-induced GluA2-associated PI3K activation. Genetic ablation of PIKE (PIKE(-/-)) in neurons suppresses GluA2-associated PI3K activation, therefore inhibiting the subsequent surface expression of GluA2 and the formation of long-term potentiation. Our findings suggest that PIKE-L is a critical factor in controlling synaptic AMPAR insertion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.