ArticleThe EMBO journal2011
An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Meta-analysis of tRNA derived RNA fragments reveals that they are evolutionarily conserved and associate with AGO proteins to recognize specific RNA targets.BMC biology · 2014Pooled it
- Dimerization of ADAR1 modulates site-specificity of RNA editing.Nature communications · 2024Article
- The Emerging Function and Promise of tRNA-Derived Small RNAs in Cancer.Journal of Cancer · 2024Review
- A Structural View of miRNA Biogenesis and Function.Non-coding RNA · 2022Review
- A Glimpse of "Dicer Biology" Through the Structural and Functional Perspective.Frontiers in molecular biosciences · 2021Review
- Function of Dicer with regard to Energy Homeostasis Regulation, Structural Modification, and Cellular Distribution.International journal of endocrinology · 2020Review
- Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2.Nucleic acids research · 2019Article
- Article
- Interaction of PKR with single-stranded RNA.Scientific reports · 2017Article
- Article
- An extended dsRBD is required for post-transcriptional modification in human tRNAs.Nucleic acids research · 2015Article
- Induced folding in RNA recognition by Arabidopsis thaliana DCL1.Nucleic acids research · 2015Article
- Swiss army knives: non-canonical functions of nuclear Drosha and Dicer.Nature reviews. Molecular cell biology · 2015Review
- A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans.Developmental cell · 2014Article
- 'Black sheep' that don't leave the double-stranded RNA-binding domain fold.Trends in biochemical sciences · 2014Review
- Human nuclear Dicer restricts the deleterious accumulation of endogenous double-stranded RNA.Nature structural & molecular biology · 2014Article
- A bimodular nuclear localization signal assembled via an extended double-stranded RNA-binding domain acts as an RNA-sensing signal for transportin 1.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Review
- The double-stranded RNA binding domain of human Dicer functions as a nuclear localization signal.RNA (New York, N.Y.) · 2013Article
- RNA recognition by double-stranded RNA binding domains: a matter of shape and sequence.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dicer proteins function in RNA interference (RNAi) pathways by generating small RNAs (sRNAs). Here, we report the solution structure of the C-terminal domain of Schizosaccharomyces pombe Dicer (Dcr1). The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel zinc-binding motif that is conserved among dicers in yeast. Although the C-terminal domain of Dcr1 still binds nucleic acids, this property is dispensable for proper functioning of Dcr1. In contrast, disruption of zinc coordination renders Dcr1 mainly cytoplasmic and leads to remarkable changes in gene expression and loss of heterochromatin assembly. In summary, our results reveal novel insights into the mechanism of nuclear retention of Dcr1 and raise the possibility that this new class of dsRBDs might generally function in nucleocytoplasmic trafficking and not substrate binding. The C-terminal domain of Dcr1 constitutes a novel regulatory module that might represent a potential target for therapeutic intervention with fungal diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.