ArticleReproductive sciences (Thousand Oaks, Calif.)2011
Differential granulosa cell gene expression in young women with diminished ovarian reserve.
Article in Reproductive sciences (Thousand Oaks, Calif.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Identification of the key regulating genes of diminished ovarian reserve (DOR) by network and gene ontology analysis.Molecular biology reports · 2016Pooled it
- Genetic associations with diminished ovarian reserve: a systematic review of the literature.Journal of assisted reproduction and genetics · 2014Pooled it
- Ferroptosis and Sterol Biosynthesis Dysregulation in Granulosa Cells of Patients with Diminished Ovarian Reserve.Antioxidants (Basel, Switzerland) · 2025Article
- Role of epigenetic regulation in diminished ovarian reserve.Journal of assisted reproduction and genetics · 2025Review
- Diminished ovarian reserve causes adverse ART outcomes attributed to effects on oxygen metabolism function in cumulus cells.BMC genomics · 2023Article
- New AMH cutoff values for warning of decreased ovarian response based on MCL characteristics in young women: a retrospective study using a propensity score-matching analysis.BMC pregnancy and childbirth · 2022Article
- Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review.Reproductive biology and endocrinology : RB&E · 2022Review
- Altered Expression of GDF9 and BMP15 Genes in Granulosa Cells of Diminished Ovarian Reserve Patients: A Case-Control Study.Cell journal · 2022Article
- Differential transcriptional profiles of human cumulus granulosa cells in patients with diminished ovarian reserve.Archives of gynecology and obstetrics · 2022Article
- Expression of pro-apoptotic and anti-apoptotic proteins in granulosa cells of women with diminished ovarian reserve.Journal of assisted reproduction and genetics · 2022Article
- Mir-484 contributes to diminished ovarian reserve by regulating granulosa cell function via YAP1-mediated mitochondrial function and apoptosis.International journal of biological sciences · 2022Article
- Novel variants in women with premature ovarian function decline identified via whole-exome sequencing.Journal of assisted reproduction and genetics · 2020Article
- Article
- Cumulus cell pappalysin-1, luteinizing hormone/choriogonadotropin receptor, amphiregulin and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 mRNA levels associate with oocyte developmental competence and embryo outcomes.Journal of assisted reproduction and genetics · 2019Article
- Compensatory Increase in Ovarian Aromatase in Older Regularly Cycling Women.The Journal of clinical endocrinology and metabolism · 2015Article
- FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner.The Journal of clinical endocrinology and metabolism · 2015Article
- Markers of stem cells in human ovarian granulosa cells: is there a clinical significance in ART?Journal of ovarian research · 2012Article
- Expression of antiapoptosis gene survivin in luteinized ovarian granulosa cells of women undergoing IVF or ICSI and embryo transfer: clinical correlations.Reproductive biology and endocrinology : RB&E · 2012Article
- Impaired gremlin 1 (GREM1) expression in cumulus cells in young women with diminished ovarian reserve (DOR).Journal of assisted reproduction and genetics · 2012Article
- Molecular crosstalk between insulin-like growth factors and follicle-stimulating hormone in the regulation of granulosa cell function.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate if a diagnosis of diminished ovarian reserve (DOR) is associated with a differential gene profile of ovarian granulosa cells (GCs) in infertile women undergoing in vitro fertilization (IVF).
designProspective Cohort Study.
settingAcademic IVF Program. PATIENTS: Infertile women <38 years were prospectively enrolled into 2 groups: normal ovarian reserve (NOR, follicle-stimulating hormone [FSH] < 10 mIU/mL, n = 4) and DOR (FSH ≥ 10.0 mIU/mL, n = 4).
interventionsCumulus (C) and mural (M) GCs were isolated at egg retrieval; messenger RNA was extracted and transcribed. MAIN OUTCOME MEASURE(S): Differential gene expression in cerebellar granule cells (CGCs) in the 2 groups was assessed by cDNA microarray. Microarray findings were validated by quantitative real-time polymerase chain reaction (qRTPCR) in CGCs and explored in multinucleated giant cells (MGCs).
resultsOf the 1256 differentially regulated genes identified in CGCs of women with DOR, the insulin-like growth factor (IGF) family was a biologically relevant gene family of a priori interest. Downregulation of IGF1 and IGF2 ligands (-3.28- and -2.54-fold, respectively), and their receptors, (-3.53- and -1.32-fold downregulation of IGF1R and IGF2R, respectively) was identified in luteinized CGCs in women with DOR compared to those with NOR. Downregulation of both IGF1 and IGF 2 ligands (-4.35- and 3.89-fold, respectively) was furthermore observed in MGCs in women with DOR compared to those with NOR; no differences in the expression of respective receptors were however observed in MGCs in the 2 groups.
conclusionsComponents of the IGF gene family are downregulated in GCs of women with DOR. These findings maybe contributory to the reproductive compromise observed in women with DOR, and merit further exploration.
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Registered trials
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