Trial reportBehavioral and brain functions : BBF2011
Functional neural correlates of reduced physiological falls risk.
Trial report in Behavioral and brain functions : BBF, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00426881 (The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65-75 Years Old), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65-75 Years Old: A 12-Month RCT
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- An ALE meta-analysis on the effects of neural changes due to exercise on executive function in a healthy population.Scientific reports · 2025Pooled it
- Three key regions for supervisory attentional control: evidence from neuroimaging meta-analyses.Neuroscience and biobehavioral reviews · 2015Pooled it
- Can two multimodal psychomotor exercise programs improve attention, affordance perception, and balance in community dwellings at risk of falling? A randomized controlled trial.BMC public health · 2022Trial
- Auditory stimulus has a larger effect on anticipatory postural adjustments in older than young adults during choice step reaction.European journal of applied physiology · 2017Article
- Age differences in reactive strategies and execution time during choice stepping with visual interference.European journal of applied physiology · 2016Article
- Correlating Gray Matter Volume with Individual Difference in the Flanker Interference Effect.PloS one · 2015Article
- Neuropsychological mechanisms of falls in older adults.Frontiers in aging neuroscience · 2014Review
- Postural adjustment errors reveal deficits in inhibition during lateral step initiation in older adults.Journal of neurophysiology · 2013Article
- Emerging concept: 'central benefit model' of exercise in falls prevention.British journal of sports medicine · 2013Article
- Overall reductions in functional brain activation are associated with falls in older adults: an fMRI study.Frontiers in aging neuroscience · 2013Article
- White Matter Volume Mediates the Relationship Between Self-Efficacy and Mobility in Older Women.Experimental aging researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundIt is currently unclear whether the function of brain regions associated with executive cognitive processing are independently associated with reduced physiological falls risk. If these are related, it would suggest that the development of interventions targeted at improving executive neurocognitive function would be an effective new approach for reducing physiological falls risk in seniors.
methodsWe performed a secondary analysis of 73 community-dwelling senior women aged 65 to 75 years old who participated in a 12-month randomized controlled trial of resistance training. Functional MRI data were acquired while participants performed a modified Eriksen Flanker Task - a task of selective attention and conflict resolution. Brain volumes were obtained using MRI. Falls risk was assessed using the Physiological Profile Assessment (PPA).
resultsAfter accounting for baseline age, experimental group, baseline PPA score, and total baseline white matter brain volume, baseline activation in the left frontal orbital cortex extending towards the insula was negatively associated with reduced physiological falls risk over the 12-month period. In contrast, baseline activation in the paracingulate gyrus extending towards the anterior cingulate gyrus was positively associated with reduced physiological falls risk.
conclusionsBaseline activation levels of brain regions underlying response inhibition and selective attention were independently associated with reduced physiological falls risk. This suggests that falls prevention strategies may be facilitated by incorporating intervention components - such as aerobic exercise - that are specifically designed to induce neurocognitive plasticity.
trial registrationClinicalTrials.gov Identifier: NCT00426881.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.