ArticleBiodemography and social biology2011
Inflammatory gene variants in the Tsimane, an indigenous Bolivian population with a high infectious load.
Article in Biodemography and social biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.Proceedings. Biological sciences · 2025Article
- A comprehensive exploration of chronic kidney disease and dialysis in Canada's Indigenous population: from epidemiology to genetic influences.International urology and nephrology · 2024Review
- Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.Scientific reports · 2024Article
- Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3.Aging and disease · 2024Article
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- Current allele distribution of the human longevity gene APOE in Europe can mainly be explained by ancient admixture.Aging cell · 2023Article
- ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers.Pharmaceutics · 2023Review
- Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- APOE genetics influence murine gut microbiome.Scientific reports · 2022Article
- The Indigenous South American Tsimane Exhibit Relatively Modest Decrease in Brain Volume With Age Despite High Systemic Inflammation.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Article
- Rapidly declining body temperature in a tropical human population.Science advances · 2020Article
- Voluntary collective isolation as a best response to COVID-19 for indigenous populations? A case study and protocol from the Bolivian Amazon.Lancet (London, England) · 2020Article
- Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Haplotype architecture of the Alzheimer's risk in theAlzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration.Frontiers in neuroscience · 2020Article
- The Genetic Variability ofGenes · 2019Review
- Low Evolutionary Selection Pressure in Senescence Does Not Explain the Persistence of Aβ in the Vertebrate Genome.Frontiers in aging neuroscience · 2019Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
The Tsimane of lowland Bolivia are an indigenous forager-farmer population living under conditions resembling pre-industrial European populations, with high infectious morbidity, high infection and inflammation, and shortened life expectancy. Analysis of 917 persons ages 5 to 60+ showed that allele frequencies of 9 SNPs examined in the apolipoprotein E (apoE), C-reactive protein (CRP), and interleukin-6 (IL-6) genes differed from some European, African, and north Asian-derived populations. The apoE2 allele was absent, whereas four SNPs related to CRP and IL-6 were monomorphic: CRP (rs1800947, rs3093061, and rs3093062) and IL-6 (rs1800795). No significant differences in apoE, CRP, and IL-6 variants across age were found CRP levels were higher in carriers of two CRP proinflammatory SNPs, whereas they were lower in carriers of apoE4. Taken together the evidence for (1) different allele frequencies between the Tsimane and other populations and (2) the correlations of CRP and apoE alleles with blood CRP may suggest that these variants are under selection in response to a high infection environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.