Trial reportOral and maxillofacial surgery2011
Effect of two routes of administration of dexamethasone on pain, edema, and trismus in impacted lower third molar surgery.
Trial report in Oral and maxillofacial surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06604286 (Postoperative Dexamethasone Injected Into Masseter Muscle and Pterygomandibular Space After Mandibular Third Molar Surgery; Comparison of Effects on Pain, Edema And Trismus), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postoperative Dexamethasone Injected Into Masseter Muscle and Pterygomandibular Space After Mandibular Third Molar Surgery; Comparison of Effects on Pain, Edema And Trismus
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.
- Corticosteroids for managing acute pain subsequent to surgical extraction of mandibular third molars: A systematic review and meta-analysis.Journal of the American Dental Association (1939) · 2023Pooled it
- Clinical effects of two ozone therapy administration methods following mandibular third molar extraction: a parallel-group randomized clinical trial with exploratory salivary biomarker assessment.Clinical oral investigations · 2026Trial
- Effects of Passiflora incarnata on salivary biomarkers and anxiety in patients undergoing third molar extraction surgery.Scientific reports · 2025Trial
- A triple-blind randomized clinical trial of different associations between dexamethasone and non-steroids anti-inflammatories for preemptive action in third molar extractions.Scientific reports · 2021Trial
- The combined use of systemic analgesic/anti-inflammatory drugs and a bioactive topical desensitizer for reduced in-office bleaching sensitivity without jeopardizing the hydrogen peroxide efficacy: a randomized, triple blinded, split-mouth clinical trial.Clinical oral investigations · 2021Trial
- Comparison of the effect of therapeutic elastic bandage, submucosal dexamethasone, or dexketoprofen trometamol on inflammatory symptoms and quality of life following third molar surgery: a randomized clinical trial.Clinical oral investigations · 2021Trial
- Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study.Clinical oral investigations · 2021Trial
- Efficacy of methylprednisolone on pain, trismus and quality of life following surgical removal of mandibular third molars: a double-blind, split-mouth, randomised controlled trial.Medicina oral, patologia oral y cirugia bucal · 2021Trial
- Effect of preemptive dexamethasone and etoricoxib on postoperative period following impacted third molar surgery - a randomized clinical trial.Medicina oral, patologia oral y cirugia bucal · 2019Trial
- Pre-operative use of dexamethasone does not reduce incidence or intensity of bleaching-induced tooth sensitivity. A triple-blind, parallel-design, randomized clinical trial.Clinical oral investigations · 2019Trial
- Clinical evaluation of two dexamethasone regimens in the extractions of impacted third molars-a randomized clinical trial.Oral and maxillofacial surgery · 2018Trial
- Effect of the local administration of betamethasone on pain, swelling and trismus after impacted lower third molar extraction. A randomized, triple blinded, controlled trial.Medicina oral, patologia oral y cirugia bucal · 2014Trial
- Age-Related Differences in Root Migration and Lesion Formation After Third-Molar Coronectomy.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Postoperative pain and influencing factors after prophylactic extraction of impacted mandibular third molars: a multicenter prospective cohort study.BMC oral health · 2025Article
- IS Intra-masseteric Dexamethasone Better than Intra-deltoid Injection in Reducing Post-operative Sequelae Following Impacted Third Molar Surgery?: A Randomized Clinical Study.Journal of maxillofacial and oral surgery · 2024Article
- The Local Route of Administration of Dexamethasone in Impacted Mandibular Third Molar Surgery: A Systematic Review and Meta-analysis of Randomised Controlled Trials and a Critical Narrative Review on the Claimed Advantages of the Local Route.Journal of maxillofacial and oral surgery · 2024Review
- A comparative evaluation of the effect of addition of 8 mg dexamethasone to 2% lignocaine with adrenaline in mandibular third molar surgery: a split mouth randomised double blind study.Frontiers in oral health · 2024Article
- Review
- Review
- Single-Dose Ibuprofen-Arginine as a Preventive for Pain, Edema, and Trismus After Impacted Lower Third Molar Surgery: A Randomized Split-Mouth Clinical Trial.European journal of dentistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study was to compare pain, edema, and trismus in the postoperative period following third molar surgery using 8 mg of dexamethasone administered either orally or through local injection.
methodsA prospective, controlled, randomized trial was carried out involving 60 lower third molar surgeries in 67 patients between October 2008 and June 2009. The sample was randomly divided into three groups: group A (local injection), group B (tablets), and group C (control). In all cases, either ostectomy or crown sectioning was employed. On the second and seventh day following surgery, linear edema was determined using facial landmarks, and maximal mouth opening measurements were performed. Postoperative pain was recorded using a visual analog scale.
resultsPatient age ranged from 14 to 37 years (mean, 21.0 years). With regard to pain, edema, and trismus, the two administration routes tested (local injection and tablets) demonstrated similar efficacy, and both methods achieved better results in comparison to the control group.
conclusionBoth the oral administration and local injection of dexamethasone proved effective in reducing pain, edema, and trismus compared to control group following lower third molar surgeries, achieving similar results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.