ReviewInternational journal of environmental research and public health2011
The protean toxicities of lead: new chapters in a familiar story.
Review in International journal of environmental research and public health, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Relation Between Low-Level Lead Exposure and Oxidative Stress: a Review of the Epidemiological Evidence in Children and Non-Occupationally Exposed Adults.Current environmental health reports · 2016Pooled it
- Mercury Exposure, Gene Expression, and Intelligence Quotient in Afro-Descendant Children from Two Colombian Regions.Toxics · 2025Article
- Pathological epigenetic events and reversibility review: the intersection between hallmarks of aging and developmental origin of health and disease.Epigenomics · 2023Review
- Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Estimating the burden of diseases attributable to lead exposure in the North Africa and Middle East region, 1990-2019: a systematic analysis for the Global Burden of Disease study 2019.Environmental health : a global access science source · 2022Article
- Bioavailable soil Pb minimized by in situ transformation to plumbojarosite.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.Environmental research · 2020Review
- Blood lead levels in antenatal women and its association with iron deficiency anemia and adverse pregnancy outcomes.Journal of family medicine and primary care · 2020Article
- New Approaches to Identifying and Reducing the Global Burden of Disease From Pollution.GeoHealth · 2020Article
- Dietary Lead and Phosphate Interactions Affect Oral Bioavailability of Soil Lead in the Mouse.Environmental science & technology · 2019Article
- The concurrent decline of soil lead and children's blood lead in New Orleans.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Prenatal lead exposure impacts cross-hemispheric and long-range connectivity in the human fetal brain.NeuroImage · 2019Article
- Long-Term in Situ Reduction in Soil Lead Bioavailability Measured in a Mouse Model.Environmental science & technology · 2018Article
- Estimates of potential childhood lead exposure from contaminated soil using the USEPA IEUBK model in Melbourne, Australia.Environmental geochemistry and health · 2018Article
- Mapping the Urban Lead Exposome: A Detailed Analysis of Soil Metal Concentrations at the Household Scale Using Citizen Science.International journal of environmental research and public health · 2018Article
- Porous FeRSC advances · 2018Article
- Preliminary assessment of surface soil lead concentrations in Melbourne, Australia.Environmental geochemistry and health · 2018Article
- Prevention of Elevated Blood Lead Levels Among Child Refugees and Other Susceptible Populations.American journal of public health · 2018Article
- Peripubertal blood lead levels and growth among Russian boys.Environment international · 2017Article
- Soil Lead and Children's Blood Lead Disparities in Pre- and Post-Hurricane Katrina New Orleans (USA).International journal of environmental research and public health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Many times in the history of lead toxicology the view that "the problem" has been solved and is no longer a major health concern has prevailed, only to have further research demonstrate the prematurity of this judgment. In the last decade, an extraordinary amount of new research on lead has illustrated, all too clearly, that "the problem" has not disappeared, and that, in fact, it has dimensions never before considered. Recent risk assessments have concluded that research has yet to identify a threshold level below which lead can be considered "safe." Although children's intelligence has traditionally been considered to be the most sensitive endpoint, and used as the basis for risk assessment and standard setting, increased lead exposure has been associated with a wide variety of other morbidities both in children and adults, in some cases at biomarker levels comparable to those associated with IQ deficits in children. In adults, these endpoints include all-cause mortality and dysfunctions in the renal, cardiovascular, reproductive, central nervous systems. In children, IQ deficits are observed at blood lead levels well below 10 μg/dL, and the dose-effect relationship appears to be supra-linear. Other health endpoints associated with greater early-life lead exposure in children include ADHD, conduct disorder, aggression and delinquency, impaired dental health, and delayed sexual maturation. Studies employing neuroimaging modalities such as volumetric, diffusion tensor, and functional MRI are providing insights into the neural bases of the cognitive impairments associated with greater lead exposure.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.