ArticleCell research2012
NOPO modulates Egr-induced JNK-independent cell death in Drosophila.
Article in Cell research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
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- The TNFR Wengen regulates the FGF pathway by an unconventional mechanism.Nature communications · 2023Article
- Toll-7 promotes tumour growth and invasion in Drosophila.Cell proliferation · 2022Article
- Dissection of the Regulatory Elements of the Complex Expression Pattern of Puckered, a Dual-Specificity JNK Phosphatase.International journal of molecular sciences · 2021Article
- Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.PLoS biology · 2021Article
- ZnT7 RNAi favors RafOncogene · 2021Article
- Toll signaling promotes JNK-dependent apoptosis inCell division · 2020Article
- Snail modulates JNK-mediated cell death in Drosophila.Cell death & disease · 2019Article
- Spz/Toll-6 signal guides organotropic metastasis inDisease models & mechanisms · 2019Article
- Characterization of TNF-induced cell death in Drosophila reveals caspase- and JNK-dependent necrosis and its role in tumor suppression.Cell death & disease · 2019Article
- Using genetic variation in Aedes aegypti to identify candidate anti-dengue virus genes.BMC infectious diseases · 2019Article
- Lic regulates JNK-mediated cell death in Drosophila.Cell proliferation · 2019Article
- MKK3 modulates JNK-dependent cell migration and invasion.Cell death & disease · 2019Article
- Article
- APLP2 Modulates JNK-Dependent Cell Migration inBioMed research international · 2018Article
- Pontin/Tip49 negatively regulates JNK-mediated cell death inCell death discovery · 2018Article
- Amyloid precursor like protein-1 promotes JNK-mediated cell migration in Drosophila.Oncotarget · 2017Article
- GLYAT regulates JNK-mediated cell death in Drosophila.Scientific reports · 2017Article
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tumor necrosis factor (TNF) family ligands play essential roles in regulating a variety of cellular processes including proliferation, differentiation and survival. Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive. To further delineate the Egr-triggered cell death pathway, we performed a genetic screen to identify dominant modifiers of the Egr-induced cell death phenotype. Here we report that Egr elicits a caspase-mediated cell death pathway independent of JNK signaling. Furthermore, we show NOPO, the Drosophila ortholog of TRIP (TRAF interacting protein) encoding an E3 ubiquitin ligase, modulates Egr-induced Caspase-mediated cell death through transcriptional activation of pro-apoptotic genes reaper and hid. Finally, we found Bendless and dUEV1a, an ubiquitin-conjugating E2 enzyme complex, regulates NOPO-triggered cell death. Our results indicate that the Ben-dUEV1a complex constitutes a molecular switch that bifurcates the Egr-induced cell death signaling into two pathways mediated by JNK and caspases respectively.
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