ArticleProceedings of the National Academy of Sciences of the United States of America2011
Sensing membrane stress with near IR-emissive porphyrins.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Electrochemical Switch-On of Nonlinear Optical Response in a Nitro-Functionalized Arylimido-Polyoxometalate.Angewandte Chemie (International ed. in English) · 2026Article
- Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores.Inorganic chemistry · 2025Article
- Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules.Angewandte Chemie (International ed. in English) · 2024Review
- Experimental Investigations on the Conductance of Lipid Membranes under Differential Hydrostatic Pressure.Membranes · 2022Article
- Dynamic multimodal holograms of conjugated organogels via dithering mask lithography.Nature materials · 2021Article
- Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation.Polymers · 2020Article
- Driving high quantum yield NIR emission through proquinoidal linkage motifs in conjugated supermolecular arrays.Chemical science · 2020Article
- Porphyrins as Colorimetric and Photometric Biosensors in Modern Bioanalytical Systems.Chembiochem : a European journal of chemical biology · 2020Review
- Streptavidin interfacing as a general strategy to localize fluorescent membrane tension probes in cells.Chemical science · 2019Article
- Visualizing Tension and Growth in Model Membranes Using Optical Dyes.Biophysical journal · 2018Article
- Microscopic mechanisms of deformation transfer in high dynamic range branched nanoparticle deformation sensors.Nature communications · 2018Article
- Tuning the Sensitivity of Fluorescent Porphyrin Dimers to Viscosity and Temperature.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Article
- Porphyrins at interfaces.Nature chemistry · 2015Review
- Caging metal ions with visible light-responsive nanopolymersomes.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Implantable nanosensors: toward continuous physiologic monitoring.Analytical chemistry · 2014Review
- Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain.Journal of medicinal chemistry · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Probes embedded within a structure can enable prediction of material behavior or failure. Carefully assembled composites that respond intelligently to physical changes within a material could be useful as intrinsic sensors. Molecular rotors are one such tool that can respond optically to physical environmental changes. Here, we propose to use molecular rotors within a polymersome membrane to report membrane stress. Using supermolecular porphyrin-based fluorophores as rotors, we characterize changes in the optical emission of these near-infrared (NIR) emissive probes embedded within the hydrophobic core of the polymersome membrane. The configuration of entrapped fluorophore depends on the available space within the membrane; in response to increased volume, emission is blue shifted. We used this feature to study how shifts in fluorescence correlate to membrane integrity, imparted by membrane stress. We monitored changes in emission of these porphyrin-based fluorophores resulting from membrane stress produced through a range of physical and chemical perturbations, including surfactant-induced lysis, hydrolytic lysis, thermal degradation, and applied stress by micropipette aspiration. This paper comprehensively illustrates the potential for supermolecular porphyrin-based fluorophores to detect intrinsic physical changes in a wide variety of environments, and suggests how molecular rotors may be used in soft materials science and biology as sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.