ArticleProceedings of the National Academy of Sciences of the United States of America2011
Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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Who cites it
40 citing papers in PubMed, 68 citations in OpenAlex.
- An enzymatic-independent function of palmitoyl hydrolase in cohesin loading onto chromosome.Nucleic acids research · 2025Article
- Parallel genetic screens identify nuclear envelope homeostasis as a key determinant of telomere entanglement resolution in fission yeast.G3 (Bethesda, Md.) · 2024Article
- Fate of telomere entanglements is dictated by the timing of anaphase midregion nuclear envelope breakdown.Nature communications · 2024Article
- SIR telomere silencing depends on nuclear envelope lipids and modulates sensitivity to a lysolipid.The Journal of cell biology · 2023Article
- Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.Life science alliance · 2023Article
- Review
- RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.Nature communications · 2022Article
- The Many Faces of Lipids in Genome Stability (and How to Unmask Them).International journal of molecular sciences · 2021Review
- Rif1 regulates telomere length through conserved HEAT repeats.Nucleic acids research · 2021Article
- Nuclear envelope tethering inhibits the formation of ALT-associated PML bodies in ALT cells.Aging · 2021Article
- Review
- Rif1 promotes association of G-quadruplex (G4) by its specific G4 binding and oligomerization activities.Scientific reports · 2019Article
- Rif1 S-acylation mediates DNA double-strand break repair at the inner nuclear membrane.Nature communications · 2019Article
- A single KH domain in Bicaudal-C links mRNA binding and translational repression functions to maternal development.Development (Cambridge, England) · 2019Article
- Article
- Compartmentalized DNA repair: Rif1Molecular & cellular oncology · 2019Article
- Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression.International journal of molecular sciences · 2018Review
- Budding yeast Rif1 binds to replication origins and protects DNA at blocked replication forks.EMBO reports · 2018Article
- Shepherding DNA ends: Rif1 protects telomeres and chromosome breaks.Microbial cell (Graz, Austria) · 2018Review
- Effect of dietary palmitic and stearic acids on sucrose motivation and hypothalamic and striatal cell signals in the rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The posttranslational addition of palmitate to cysteines occurs ubiquitously in eukaryotic cells, where it functions in anchoring target proteins to membranes and in vesicular trafficking. Here we show that the Saccharomyces cerevisiae palmitoyltransferase Pfa4 enhanced heterochromatin formation at the cryptic mating-type loci HMR and HML via Rif1, a telomere regulatory protein. Acylated Rif1 was detected in extracts from wild-type but not pfa4Δ mutant cells. In a pfa4Δ mutant, Rif1-GFP dispersed away from foci positioned at the nuclear periphery into the nucleoplasm. Sir3-GFP distribution was also perturbed, indicating a change in the nuclear dynamics of heterochromatin proteins. Genetic analyses indicated that PFA4 functioned upstream of RIF1. Surprisingly, the pfa4Δ mutation had only mild effects on telomeric regulation, suggesting Rif1's roles at HM loci and telomeres were more complexly related than previously thought. These data supported a model in which Pfa4-dependent palmitoylation of Rif1 anchored it to the inner nuclear membrane, influencing its role in heterochromatin dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.