ArticleThe Journal of biological chemistry2011
Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- A human-specific non-coding RNA for EFHC1, an epilepsy-associated gene, regulates neural stem cell proliferation for cortical development.Stem cell reports · 2026Article
- RNAa-Mediated Gene Activation in the Regulation of Stem Cell Fate.Biomolecules · 2025Review
- Natural antisense transcripts as versatile regulators of gene expression.Nature reviews. Genetics · 2024Review
- Article
- Flipons and small RNAs accentuate the asymmetries of pervasive transcription by the reset and sequence-specific microcoding of promoter conformation.The Journal of biological chemistry · 2023Review
- Regulation of HAND2 Expression by LncRNAJournal of the Endocrine Society · 2023Article
- Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cells.Molecular psychiatry · 2021Article
- Dissecting the transcriptional regulatory networks of promoter-associated noncoding RNAs in development and cancer.Journal of experimental & clinical cancer research : CR · 2020Review
- Evolutionary acquisition of promoter-associated non-coding RNA (pancRNA) repertoires diversifies species-dependent gene activation mechanisms in mammals.BMC genomics · 2017Article
- Non-coding RNAs in skeletal muscle regeneration.Non-coding RNA research · 2017Review
- Bidirectional promoters link cAMP signaling with irreversible differentiation through promoter-associated non-coding RNA (pancRNA) expression in PC12 cells.Nucleic acids research · 2016Article
- SUMOylation of HP1α supports association with ncRNA to define responsiveness of breast cancer cells to chemotherapy.Oncotarget · 2016Article
- Article
- Head-to-head antisense transcription and R-loop formation promotes transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Gene activation-associated long noncoding RNAs function in mouse preimplantation development.Development (Cambridge, England) · 2015Article
- Delta-like 4 mRNA is regulated by adjacent natural antisense transcripts.Vascular cell · 2015Article
- The varied roles of nuclear argonaute-small RNA complexes and avenues for therapy.Molecular therapy. Nucleic acids · 2014Review
- Epigenetic setting and reprogramming for neural cell fate determination and differentiation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals.BMC genomics · 2014Article
- Progress in microRNA delivery.Journal of controlled release : official journal of the Controlled Release Society · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing number of noncoding RNAs (ncRNAs) are thought to be involved in sequence-specific alterations of epigenetic processes, mostly causing gene repression. In this study, promoter-associated ncRNAs (pancRNAs >200 nucleotides in size) that were endogenously generated from the sense strand at Map2b, antisense strand at Nefl, and both strands at Vim were investigated regarding their epigenetic potential as positive or negative regulators in rat pheochromocytoma (PC12) and fibroblast (normal rat kidney) cell lines. The respective antisense pancRNAs were associated with several active chromatin marks at the Nefl and Vim promoters. Forced expression of fragments expressing the antisense pancRNAs caused sequence-specific DNA demethylation, whereas a decrease of expression induced methylation of the same sequences. In contrast, perturbing the expression of the two sense pancRNAs did not change the DNA methylation status. These results suggest that a fraction of naturally occurring ncRNAs acts in cis as a single-stranded form and that the transcriptional orientation of pancRNA is important for the establishment of sequence-specific epigenetic modifications consistent with open chromatin structure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.