ArticleThe Journal of biological chemistry2011
Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Advances in the biosynthesis and metabolic engineering of rare ginsenosides.Applied microbiology and biotechnology · 2023Review
- Oxidative stress response pathways in fungi.Cellular and molecular life sciences : CMLS · 2022Review
- Identification of Kic1p and Cdc42p as Novel Targets to Engineer Yeast Acetic Acid Stress Tolerance.Frontiers in bioengineering and biotechnology · 2022Article
- Regulation of Reactive Oxygen Species Promotes Growth and Carotenoid Production Under Autotrophic Conditions inFrontiers in microbiology · 2022Article
- The Adaptive Potential of the Middle Domain of Yeast Hsp90.Molecular biology and evolution · 2021Article
- Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis.Frontiers in bioengineering and biotechnology · 2020Review
- Yeast AP-1 like transcription factors (Yap) and stress response: a current overview.Microbial cell (Graz, Austria) · 2019Review
- A scaffold protein that chaperones a cysteine-sulfenic acid in HNature chemical biology · 2017Article
- Redox regulation: Scaffolding HNature chemical biology · 2017Article
- A Pap1-Oxs1 signaling pathway for disulfide stress in Schizosaccharomyces pombe.Nucleic acids research · 2017Article
- Orphan proteins of unknown function in the mitochondrial intermembrane space proteome: New pathways and metabolic cross-talk.Biochimica et biophysica acta · 2016Review
- Oxidative folding in the mitochondrial intermembrane space: A regulated process important for cell physiology and disease.Biochimica et biophysica acta · 2016Review
- A Network of Paralogous Stress Response Transcription Factors in the Human Pathogen Candida glabrata.Frontiers in microbiology · 2016Article
- ChiNet uncovers rewired transcription subnetworks in tolerant yeast for advanced biofuels conversion.Nucleic acids research · 2015Article
- Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans.PloS one · 2015Article
- Candida glabrata: a review of its features and resistance.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Review
- Loss of the thioredoxin reductase Trr1 suppresses the genomic instability of peroxiredoxin tsa1 mutants.PloS one · 2014Article
- Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.Antioxidants & redox signaling · 2013Article
- Automated quantification of the subcellular localization of multicompartment proteins via Q-SCAn.Traffic (Copenhagen, Denmark) · 2013Article
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3 authors at 1 institution in 1 country.
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Abstract
The Saccharomyces cerevisiae transcription factor Yap1 is a central determinant of oxidative stress tolerance. This protein is found primarily in the cytoplasm in the absence of oxidative stress but, upon exposure to oxidants, rapidly translocates to the nucleus and activates expression of target genes. Although both diamide and H(2)O(2) have been used to impose oxidative stress on cells, these different oxidants trigger Yap1 nuclear localization in distinctly different ways. Diamide appears to oxidize particular cysteine residues on Yap1, leading to inhibition of association of Yap1 with the nuclear exportin Crm1. Crm1 would normally transport Yap1 out of the nucleus. H(2)O(2) activation of Yap1 nuclear localization requires the participation of the glutathione peroxidase Gpx3 and the Yap1-binding protein Ybp1. H(2)O(2) exposure triggers formation of a dual disulfide bonded Yap1 that is catalyzed by the presence of Gpx3 and Ybp1. In the current study, we have determined that two distinct pools of Yap1 exist in the cell. These pools are designated by the level of Ybp1. Ybp1 interacts directly with Yap1 and these proteins form a stable complex in vivo. Genetic and biochemical experiments indicate that Ybp1 is rate-limiting for Yap1 oxidative folding during H(2)O(2) stress. The fungal pathogen Candida glabrata expresses a protein homologous to Ybp1 called CgYbp1. Overproduction of CgYbp1 elevated H(2)O(2) tolerance in this pathogen indicating that the determinative role of Ybp1 in setting the level of H(2)O(2) resistance has been evolutionarily conserved.
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