ArticleGenome research2012
Genetic variation in radiation-induced cell death.
Article in Genome research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
- Scientific and Clinical Studies on Variation in Individual Response to Ionising Radiation: A Scoping Review.Cureus · 2026Review
- Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.PloS one · 2026Article
- Ionising radiation exposure-induced regulation of selected biomarkers and their impact in cancer and treatment.Frontiers in nuclear medicine · 2024Review
- Gene expression variability in long-term survivors of childhood cancer and cancer-free controls in response to ionizing irradiation.Molecular medicine (Cambridge, Mass.) · 2023Article
- Transcriptomics for radiation biodosimetry: progress and challenges.International journal of radiation biology · 2023Review
- Radiation-mediated supply of genetic variation outweighs the effects of selection and drift in Chernobyl Daphnia populations.Journal of evolutionary biology · 2022Article
- Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes.eLife · 2021Article
- Establishment of a Transformation CoupledFrontiers in oncology · 2020Article
- Genomic and transcriptomic comparison of post-radiation versus sporadic sarcomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Monitoring of platelet function parameters and microRNA expression levels in patients with prostate cancer treated with volumetric modulated arc radiotherapy.Oncology letters · 2018Article
- Unexplored therapeutic opportunities in the human genome.Nature reviews. Drug discovery · 2018Review
- Novel Combined Immune Deficiency and Radiation Sensitivity Blended Phenotype in an Adult with Biallelic Variations inFrontiers in immunology · 2017Article
- Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways.Oncotarget · 2016Article
- DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging.European heart journal · 2016Review
- Overexpression of synuclein-γ predicts lack of benefit from radiotherapy for breast cancer patients.BMC cancer · 2016Article
- Selected heterozygosity at cis-regulatory sequences increases the expression homogeneity of a cell population in humans.Genome biology · 2016Article
- Differences in DNA Repair Capacity, Cell Death and Transcriptional Response after Irradiation between a Radiosensitive and a Radioresistant Cell Line.Scientific reports · 2016Article
- Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer.Genetics and molecular biology · 2015Article
- Assessment of the Radiation Effects of Cardiac CT Angiography Using Protein and Genetic Biomarkers.JACC. Cardiovascular imaging · 2015Article
- Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Radiation exposure through environmental, medical, and occupational settings is increasingly common. While radiation has harmful effects, it has utility in many applications such as radiotherapy for cancer. To increase the efficacy of radiation treatment and minimize its risks, a better understanding of the individual differences in radiosensitivity and the molecular basis of radiation response is needed. Here, we integrated human genetic and functional genomic approaches to study the response of human cells to radiation. We measured radiation-induced changes in gene expression and cell death in B cells from normal individuals. We found extensive individual variation in gene expression and cellular responses. To understand the genetic basis of this variation, we mapped the DNA sequence variants that influence expression response to radiation. We also identified radiation-responsive genes that regulate cell death; silencing of these genes by small interfering RNA led to an increase in radiation-induced cell death in human B cells, colorectal and prostate cancer cells. Together these results uncovered DNA variants that contribute to radiosensitivity and identified genes that can be targeted to increase the sensitivity of tumors to radiation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.