ArticleThe Journal of physiology2011
Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Muscle sympathetic nerve activity in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Effect of respiratory rehabilitation techniques on the autonomic function in patients with chronic obstructive pulmonary disease: A systematic review.Chronic respiratory disease · 2017Pooled it
- Sex differences in the sympathetic neurocirculatory responses to chemoreflex activation.The Journal of physiology · 2022Trial
- Inhaled β-agonist does not modify sympathetic activity in patients with COPD.BMC pulmonary medicine · 2015Trial
- Respiratory modulation of sympathetic transduction to blood pressure in health and type 2 diabetes.The Journal of physiology · 2024Article
- Aging in females is associated with changes in respiratory modulation of sympathetic nerve activity and blood pressure.American journal of physiology. Heart and circulatory physiology · 2023Article
- Sex differences in the effect of acute intermittent hypoxia on respiratory modulation of sympathetic activity.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The need for specificity in quantifying neurocirculatory vs. respiratory effects of eucapnic hypoxia and transient hyperoxia.The Journal of physiology · 2020Article
- Neuronal Networks in Hypertension: Recent Advances.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.Journal of neurophysiology · 2019Article
- Update on Chemoreception: Influence on Cardiorespiratory Regulation and Pathophysiology.Clinics in chest medicine · 2019Review
- A Comparison of Muscle Sympathetic Nerve Activity to Non-contracting Muscle During Isometric Exercise in the Upper and Lower Limbs.Frontiers in neuroscience · 2019Article
- Increased Respiratory Modulation of Blood Pressure in Hypertensive Patients.Frontiers in physiology · 2019Article
- Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus.The Journal of physiology · 2018Review
- The metaboreflex does not contribute to the increase in muscle sympathetic nerve activity to contracting muscle during static exercise in humans.The Journal of physiology · 2018Article
- Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats.Current hypertension reports · 2018Review
- Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death.Frontiers in neurology · 2017Review
- Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease.Biological research · 2016Review
- Blood Pressure Profile and Hypertensive Organ Damage in COPD Patients and Matched Controls. The RETAPOC Study.PloS one · 2016Observational
- Influence of age on respiratory modulation of muscle sympathetic nerve activity, blood pressure and baroreflex function in humans.Experimental physiology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined cardiac and respiratory modulation of muscle sympathetic nerve activity (MSNA) in 13 patients with essential hypertension (HT) and 15 with chronic obstructive pulmonary disease (COPD), and compared these with a group of young healthy controls (YHC) and older healthy controls (OHC). There were no significant differences in age of the OHC and HT subjects. MSNA was recorded via a tungsten microelectrode inserted percutaneously into the common peroneal nerve. Respiration was recorded by a strain-gauge transducer around the chest and ECG recorded by surface electrodes. Cardiac and respiratory modulation of MSNA was quantified by fitting polynomials to the cross-correlation histograms constructed between the sympathetic spikes and ECG or respiration. Cardiac modulation was high across all groups, but was significantly lower in COPD (75.9 ± 4.4%) than in the HT (92.4 ± 3.0%), OHC (93.7 ± 1.3%) or YHC (89.1 ± 1.6%) groups. Across all groups, respiratory modulation was significantly lower than cardiac modulation. Respiratory modulation in HT (45.2 ± 5.7%) and COPD (37.5 ± 6.3%) was not higher than in the OHC (47.2 ± 5.4%) or YHC (49.5 ± 6.0%) groups. We have shown that respiratory modulation of MSNA is present in all groups, is consistently lower than the magnitude of cardiac modulation, and is not increased in HT or COPD, arguing against an amplified respiratory-sympathetic coupling in hypertension. Moreover, given that patients with COPD are chronically asphyxic, these data indicate that an increased chemical drive does not increase respiratory modulation of MSNA.
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Registered trials
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