ArticleNeuroscience2011
Spatial and temporal expression patterns of nicotinic acetylcholine α9 and α10 subunits in the embryonic and early postnatal inner ear.
Article in Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Loss of α-9 Nicotinic Acetylcholine Receptor Subunit Predominantly Results in Impaired Postural Stability Rather Than Gaze Stability.Frontiers in cellular neuroscience · 2021Article
- Characterization of HA-tagged α9 and α10 nAChRs in the mouse cochlea.Scientific reports · 2020Article
- A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications.Journal of neurophysiology · 2020Review
- Talking back: Development of the olivocochlear efferent system.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- Commentary: Nicotinic Acetylcholine Receptor α9 and α10 Subunits Are Expressed in the Brain of Mice.Frontiers in cellular neuroscience · 2018Article
- ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells.Journal of neurophysiology · 2018Article
- Perinatal nicotine exposure impairs the maturation of glutamatergic inputs in the auditory brainstem.The Journal of physiology · 2017Article
- Nicotinic acetylcholine receptors regulate vestibular afferent gain and activation timing.The Journal of comparative neurology · 2017Article
- Electrophysiological Measurements of Peripheral Vestibular Function-A Review of Electrovestibulography.Frontiers in systems neuroscience · 2017Review
- Generation and Characterization of α9 and α10 Nicotinic Acetylcholine Receptor Subunit Knockout Mice on a C57BL/6J Background.Frontiers in neuroscience · 2017Article
- Assessment of the expression and role of the α1-nAChR subunit in efferent cholinergic function during the development of the mammalian cochlea.Journal of neurophysiology · 2016Article
- Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Gentamicin blocks the ACh-induced BK current in guinea pig type II vestibular hair cells by competing with Ca²⁺ at the L-type calcium channel.International journal of molecular sciences · 2014Article
- The expression of nicotinic receptor alpha7 during cochlear development.Brain and behavior · 2012Article
- New developments in understanding the mechanisms and function of spontaneous electrical activity in the developing mammalian auditory system.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The expression and function of nicotinic receptor subunits (nAChRs) in the inner ear before the onset of hearing is not well understood. We investigated the mRNA expression of the α9 and α10 nAChR subunits in sensory hair cells of the embryonic and postnatal rat inner ear. We mapped their spatial and temporal expression in cochlear and vestibular hair cells using qPCR, [35S] labeled cRNA in situ hybridization, and α-bungarotoxin (α-Bgt) to label the presumptive membrane-bound receptor on cochlear hair cells. The results suggest that (1) the mRNA expression of the α9 subunit precedes expression of the α10 subunit in both cochlear and vestibular hair cells, (2) the mRNA expression of both the α9 and α10 subunits occurs earlier in the vestibular system than in the cochlea, (3) the mRNA expression of both subunits is required for the assembled receptor complexes, and (4) the presumptive assembled receptor, at least in the cochlea, is associated with synapse formation and the onset of function.
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Registered trials
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