Evidence map›Paper›PMID 21843589›Full record

ReviewBiochimie2011

Non-coding RNA and antisense RNA. Nature's trash or treasure?

Stuart Knowling, Kevin V Morris

Open access · greenAbstract readReview
In one paragraph

Review in Biochimie, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. RNA Modifications Meet Tumors.Cancer management and research · 2022
    Review
  8. MIAT, a potent CVD-promoting lncRNA.Cellular and molecular life sciences : CMLS · 2021
    Article
  9. Article
  10. Article
  11. Role of Exosomal Non-Coding RNAs in Bone-Related Diseases.Frontiers in cell and developmental biology · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Function and Clinical Implications of Long Non-Coding RNAs in Melanoma.International journal of molecular sciences · 2017
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Stuart KnowlingDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. knowling@scripps.edu
Kevin V Morris
Scripps Research Institute · US

Funding

Activation of silenced tumor suppressor genes by non-coding RNAR01CA151574 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI VOGT, PETER K · 2010 to 2014
$1.9M
The Antisense Transcriptome and the Epigenetics of Cancer.R01CA153124 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI VOGT, PETER K · 2010 to 2013
$1.2M
Non-coding RNAs involved in HIV-1 LatencyR01AI084406 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI MORRIS, KEVIN V · 2009 to 2010
$889k
NCI NIH HHS R01 CA151574NCI NIH HHS R01 CA153124NIAID NIH HHS R01 AI084406
6 · The paper itself

Abstract

Although control of cellular function has classically been considered the responsibility of proteins, research over the last decade has elucidated many roles for RNA in regulation of not only the proteins that control cellular functions but also for the cellular functions themselves. In parallel to this advancement in knowledge about the regulatory roles of RNA there has been an explosion of knowledge about the role that epigenetics plays in controlling not only long-term cellular fate but also the short-term regulatory control of genes. Of particular interest is the crossover between these two worlds, a world where RNA can act out its part and subsequently elicit chromatin modifications that alter cellular function. Two main categories of RNA are examined here, non-coding RNA and antisense RNA both of which perform vital functions in controlling numerous genes, proteins and RNA itself. As the activities of non-coding and antisense RNA in both normal and aberrant cellular function are elucidated, so does the number of possible targets for pharmacopeic intervention.

Indexed as

Epigenesis, GeneticAnimalsChromatin Assembly and DisassemblyGene Expression RegulationGenomic ImprintingHumansPluripotent Stem CellsRNA, AntisenseRNA, UntranslatedTranscription, GeneticX Chromosome InactivationRNA, AntisenseRNA, Untranslated

Identifiers

PMID21843589
PMCPMC3195647
OpenAlexW2024628274

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.