ArticleHuman immunology2011
MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection.
Article in Human immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Genetic polymorphisms as multi-biomarkers in severe acute respiratory syndrome (SARS) by coronavirus infection: A systematic review of candidate gene association studies.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Pooled it
- Association between MASP2 gene polymorphisms and susceptibility to Covid-19 in Iranian patients: a case-control study.BMC infectious diseases · 2025Article
- Evaluation of the significance of complement-related genes mutations in atypical postinfectious glomerulonephritis: a pilot study.International urology and nephrology · 2024Article
- DNA Polymorphisms and mRNA Levels of Immune Biomarkers as Candidates for Inflammatory Postpartum Disorders Susceptibility in Italian Buffaloes.Veterinary sciences · 2023Article
- Association between mannose binding lectin gene polymorphisms and clinical severity of COVID-19 in children.Molecular biology reports · 2023Article
- Mannose-binding lectin gene 2 variant DD (rs 5030737) is associated with susceptibility to COVID-19 infection in the urban population of Patna City (India).Molecular genetics and genomics : MGG · 2023Article
- Article
- Impact of MASP2 gene polymorphism and gene-tea drinking interaction on susceptibility to tuberculosis.Scientific reports · 2021Article
- Review
- "Complimenting the Complement": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma.Frontiers in oncology · 2020Review
- Effects of hMASP-2 on the formation of BCG infection-induced granuloma in the lungs of BALB/c mice.Scientific reports · 2017Article
- MBL-associated serine proteases (MASPs) and infectious diseases.Molecular immunology · 2015Review
- Impact of MBL and MASP-2 gene polymorphism and its interaction on susceptibility to tuberculosis.BMC infectious diseases · 2015Article
- Genetic variants of innate immune receptors and infections after liver transplantation.World journal of gastroenterology · 2014Review
- The lectin pathway of complement and rheumatic heart disease.Frontiers in pediatrics · 2014Review
- Mannan binding lectin-associated serine protease 1 is induced by hepatitis C virus infection and activates human hepatic stellate cells.Clinical and experimental immunology · 2013Article
- Learning natural selection from the site frequency spectrum.Genetics · 2013Article
- Leprosy association with low MASP-2 levels generated by MASP2 haplotypes and polymorphisms flanking MAp19 exon 5.PloS one · 2013Article
- Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) has become a major public health issue and is prevalent in most countries. We examined several MASP2 functional polymorphisms in 104 Brazilian patients with moderate and severe chronic hepatitis C using the primers set to amplify the region encoding the first domain (CUB1), a critical region for the formation of functional mannan-binding lectin (MBL)/MBL-associated serine proteases (MASP)-2 complexes, and the fifth domain (CCP2), which is essential for C4 cleavage of the MASP2 gene. We identified five single nucleotide polymorphisms in patients and controls: p. R99Q, p. D120G, p.P126L, p.D371Y, and p.V377A. Our results show that the p.D371Y variant (c.1111 G > T) is associated with susceptibility to HCV infection (p = 0.003, odds ratio = 6.33, 95% confidence interval = 1.85-21.70). Considered as a dominant function for the T allele, this variant is associated with high plasma levels of the MASP-2 in hepatitis C patients (p < 0.001). However, further functional investigations are necessary to understand the degree of involvement between MASP2 and the HCV susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.