ArticleThe American journal of pathology2011
A detrimental role for invariant natural killer T cells in the pathogenesis of experimental dengue virus infection.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- License to Kill: When iNKT Cells Are Granted the Use of Lethal Cytotoxicity.International journal of molecular sciences · 2020Review
- T-cells producing multiple combinations of IFNγ, TNF and IL10 are associated with mild forms of dengue infection.Immunology · 2020Observational
- Contemporary Strategies and Current Trends in Designing Antiviral Drugs against Dengue Fever via Targeting Host-Based Approaches.Microorganisms · 2019Review
- Intracellular Pathogens: Host Immunity and Microbial Persistence Strategies.Journal of immunology research · 2019Review
- Article
- Mosquito saliva alone has profound effects on the human immune system.PLoS neglected tropical diseases · 2018Article
- Immune-mediated cytokine storm and its role in severe dengue.Seminars in immunopathology · 2017Review
- West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells.Clinical and experimental immunology · 2016Article
- Expansion of highly activated invariant natural killer T cells with altered phenotype in acute dengue infection.Clinical and experimental immunology · 2016Article
- Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection.Frontiers in immunology · 2016Review
- Dengue virus requires the CC-chemokine receptor CCR5 for replication and infection development.Immunology · 2015Article
- Organ-specific protective role of NKT cells in virus-induced inflammatory demyelination and myocarditis depends on mouse strain.Journal of neuroimmunology · 2015Article
- Regulation of NKT Cell Localization in Homeostasis and Infection.Frontiers in immunology · 2015Review
- iNKT Cells and Their Potential Lipid Ligands during Viral Infection.Frontiers in immunology · 2015Review
- Invariant NKT cell response to dengue virus infection in human.PLoS neglected tropical diseases · 2014Article
- Dengue virus infection: current concepts in immune mechanisms and lessons from murine models.Immunology · 2014Review
- NK Cells during Dengue Disease and Their Recognition of Dengue Virus-Infected cells.Frontiers in immunology · 2014Review
- Dengue in India.The Indian journal of medical research · 2012Review
- Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages.The Journal of biological chemistry · 2012Article
- Invariant NKT cells: regulation and function during viral infection.PLoS pathogens · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue virus (DENV), a member of the mosquito-borne flaviviruses, is a serious public health problem in many tropical countries. We assessed the in vivo physiologic contribution of invariant natural killer T (iNKT) cells, a population of nonconventional lipid-reactive αβ T lymphocytes, to the host response during experimental DENV infection. We used a mouse-adapted DENV serotype 2 strain that causes a disease that resembles severe dengue in humans. On DENV challenge, splenic and hepatic iNKT cells became activated insofar as CD69 and Fas ligand up-regulation and interferon-γ production. C57BL/6 mice deficient in iNKT cells (Jα18(-/-)) were more resistant to lethal infection than were wild-type animals, and the phenotype was reversed by adoptive transfer of iNKT cells to Jα18(-/-) animals. The absence of iNKT cells in Jα18(-/-) mice was associated with decreased systemic and local inflammatory responses, less liver injury, diminished vascular leak syndrome, and reduced activation of natural killer cells and neutrophils. iNKT cell functions were not necessary for control of primary DENV infection, after either natural endogenous activation or exogenous activation with the canonical iNKT cell agonist α-galactosylceramide. Together, these data reveal a novel and critical role for iNKT cells in the pathogenesis of severe experimental dengue disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.