Evidence map›Paper›PMID 21843489›Full record

ArticleBiophysical journal2011

Stoichiometry of reconstituted high-density lipoproteins in the hydrated state determined by photon antibunching.

Sonny Ly, Jitka Petrlova, Thomas Huser, Samantha Fore, Tingjuan Gao, John Voss, Ted A Laurence

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sonny LyPhysical and Life Science Directorate, Lawrence Livermore National Laboratory, Livermore, California, USA.
Jitka Petrlova
Thomas Huser
Samantha Fore
Tingjuan Gao
John Voss
Ted A Laurence
University of California, Davis · USLawrence Livermore National Laboratory · USU.S. National Science Foundation · US

Funding

The structural basis of apoE4's role in Alzheimer's DiseaseR01AG029246 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VOSS, JOHN CARL · 2007 to 2011
$1.3M
NIA NIH HHS R01 AG029246
6 · The paper itself

Abstract

Apolipoprotein A-I plays a central role in the solution structure of high-density lipoproteins. Determining the stoichiometry of lipid-bound apo A-I in the hydrated state is therefore fundamental to understanding how high-density lipoproteins form and function. Here, we use the quantum optical phenomenon of photon antibunching to determine the number of apo A-I molecules bound to discoidal lipoproteins and compare this with values obtained by photon-counting histogram analysis. Both the photon antibunching and photon-counting analyses show that reconstituted high-density lipoprotein particles contain two apo A-I molecules, which is in agreement with the commonly accepted double-belt model.

Indexed as

PhotonsApolipoprotein A-IBiophysicsLipoproteins, HDLProtein ConformationSpectrometry, FluorescenceWaterApolipoprotein A-ILipoproteins, HDLWater

Identifiers

PMID21843489
PMCPMC3175089
OpenAlexW2052503992

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.