ArticleDiabetic medicine : a journal of the British Diabetic Association2011
Obstetric and perinatal outcomes in pregnancies complicated by Type 1 and Type 2 diabetes: influences of glycaemic control, obesity and social disadvantage.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05479214 (Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy on Glycemic Control, Fetal and Neonatal Outcomes ,Randomized Controlled Trial), which is not on this map. Cited by 54 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Adding Metformin to Insulin in Uncontrolled Diabetic Patients During the 3rd Trimester of Pregnancy on Glycemic Control, Fetal and Neonatal Outcomes ,Randomized Controlled Trial
Who cites it
54 citing papers in PubMed, 3 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Effect of Prenatal Care on Perinatal Outcomes of Pregnant Women with Diabetes Mellitus: A Systematic Review.The Yale journal of biology and medicine · 2024Pooled it
- Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022 · on this mapPooled it
- An update on diabetic women obstetrical outcomes linked to preconception and pregnancy glycemic profile: a systematic literature review.TheScientificWorldJournal · 2013Pooled it
- Patterns of antenatal corticosteroid administration in a cohort of women with diabetes in pregnancy.PloS one · 2020Trial
- Metformin in women with type 2 diabetes in pregnancy (MiTy): a multi-center randomized controlled trial.BMC pregnancy and childbirth · 2016Trial
- Poor pregnancy outcome in women with type 1 diabetes is predicted by elevated HbA1c and spikes of high glucose values in the third trimester.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014Trial
- Exploring the associations of overweight and obesity with pregnancy outcomes in type 1 and type 2 diabetes: An Australian retrospective cohort study.Journal of diabetes investigation · 2026Article
- Body Weight-Related Parameters in Pregnancies Complicated by Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis with Maternal and Perinatal Outcome Mapping.Journal of clinical medicine · 2026Review
- A call to action: A consensus statement on knowledge gaps and research priorities on the management of women with early onset type 2 diabetes in the preconception, pregnancy and postnatal periods: A report from the Diabetic Medicine Symposium at the Diabetes UK Annual Professional Conference, 2025.Diabetic medicine : a journal of the British Diabetic Association · 2026Article
- Pregnancy Outcomes in Women with Type 1 Diabetes by Socioeconomic and Mental Health Disadvantages.Clinical epidemiology · 2026Article
- A model for the human fetal ventricular myocyte electrophysiology.PLoS computational biology · 2026Article
- Predictors of Composite Maternal and Fetal Outcomes among Pregnant Women with Early-Onset Type 2 Diabetes: A Cross-Sectional Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2025Article
- Differential Effects of First and Third Trimester HbA1c Levels on Neonatal Weight and Placental Mediation in Type 1 Diabetes.Frontiers in endocrinology · 2025Observational
- Pregnancy outcomes in type 2 versus type 1 diabetes: systematic review with meta-analyses.Endocrine connections · 2024Article
- Understanding the Genetic Landscape of Gestational Diabetes: Insights into the Causes and Consequences of Elevated Glucose Levels in Pregnancy.Metabolites · 2024Review
- All Children Deserve to Be Safe, Mothers Too: Evidence and Rationale Supporting Continuous Glucose Monitoring Use in Gestational Diabetes Within the Medicaid Population.Journal of diabetes science and technology · 2024Review
- Diabetes and pregnancy study (DAPSY): a 10-year single-center cohort study of pregnancies affected by diabetes.Archives of gynecology and obstetrics · 2024Article
- A Bayesian network perspective on neonatal pneumonia in pregnant women with diabetes mellitus.BMC medical research methodology · 2023Article
- Correlation between high serum ferritin levels and adverse pregnancy outcomes in women with gestational diabetes mellitus.Heliyon · 2023Article
- Potentially modifiable risk factors of preterm delivery in women with type 1 and type 2 diabetes.Diabetologia · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
aimsTo compare obstetric and perinatal outcomes in women with Type 1 and Type 2 diabetes and relate these to maternal risk factors.
methodsProspective cohort study of 682 consecutive diabetic pregnancies in East Anglia during 2006-2009. Relationships between congenital malformation, perinatal mortality and perinatal morbidity (large for gestational age, preterm delivery, neonatal care) with maternal age, parity, ethnicity, glycaemic control, obesity and social disadvantage were examined using bivariable and multivariate models.
resultsThere were 408 (59.8%) Type 1 and 274 (40.2%) Type 2 diabetes pregnancies. Women with Type 2 diabetes were older (P < 0.001), heavier (P < 0.0001), more frequently multiparous (P < 0.001), more ethnically diverse (p < 0.0001) and more socially disadvantaged (P = 0.0004). Although women with Type 2 diabetes had shorter duration of diabetes (P < 0.0001) and better pre-conception glycaemic control [HbA(1c) 52 mmol/mol (6.9%) Type 2 diabetes vs. 63 mmol/l (7.9%) Type 1 diabetes; p < 0.0001), rates of congenital malformation and perinatal mortality were comparable. Women with Type 2 diabetes had fewer large-for-gestational-age infants (37.6 vs. 52.9%, P < 0.0008), fewer preterm deliveries (17.5 vs. 37.1%, P < 0.0001) and their offspring had fewer neonatal care admissions (29.8 vs. 43.2%, P = 0.001). Third trimester HbA(1c) (OR 1.35, 95% CI 1.09-1.67, P = 0.006) and social disadvantage (OR 0.80, 95% CI 0.67-0.98; P = 0.03) were risk factors for large for gestational age.
conclusionsDespite increased age, parity, obesity and social disadvantage, women with Type 2 diabetes had better glycaemic control, fewer large-for-gestational-age infants, fewer preterm deliveries and fewer neonatal care admissions. Better tools are needed to improve glycaemic control and reduce the rates of large for gestational age, particularly in Type 1 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.