ArticleEuropean journal of applied physiology2012
Gene expression in distinct regions of rat tendons in response to jump training combined with anabolic androgenic steroid administration.
Article in European journal of applied physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Anabolic Androgenic Steroids in Orthopaedic Surgery: Current Concepts and Clinical Applications.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2022Pooled it
- Paternal Resistance Exercise Modulates Skeletal Muscle Remodeling Pathways in Fathers and Male Offspring Submitted to a High-Fat Diet.Frontiers in physiology · 2021Article
- Detraining and Anabolic-Androgenic Steroid Discontinuation Change Calcaneal Tendon Morphology.Journal of functional morphology and kinesiology · 2018Article
- Tendon Remodeling in Response to Resistance Training, Anabolic Androgenic Steroids and Aging.Cells · 2018Review
- Moderate treadmill running exercise prior to tendon injury enhances wound healing in aging rats.Oncotarget · 2016Article
- Cryotherapy Reduces Inflammatory Response Without Altering Muscle Regeneration Process and Extracellular Matrix Remodeling of Rat Muscle.Scientific reports · 2016Article
- Regional molecular and cellular differences in the female rabbit Achilles tendon complex: potential implications for understanding responses to loading.Journal of anatomy · 2014Article
- MMP inhibition as a potential method to augment the healing of skeletal muscle and tendon extracellular matrix.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Review
- Article
Corrections and comments
- Erratum issuedMarqueti, Rita de Cássia [corrected to Marqueti, Rita Cássia]
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the expression of key genes responsible for tendon remodeling of the proximal and distal regions of calcaneal tendon (CT), intermediate and distal region of superficial flexor tendon (SFT) and proximal, intermediate and distal region of deep flexor tendon (DFT) submitted to 7 weeks of jumping water load exercise in combination with AAS administration. Wistar male rats were grouped as follows: sedentary (S), trained (jumping water load exercise) (T), sedentary animals treated with AAS (5 mg/kg, twice a week) and animals treated with AAS and trained (AAST). mRNA levels of COL1A1, COL3A1, TIMP-1, TIMP-2, MMP-2, IGF-IEa, GAPDH, CTGF and TGF-β-1 were evaluated by quantitative PCR. Our main results indicated that mRNA levels alter in different regions in each tendon of sedentary animals. The training did not alter the expression of COL1A1, COL3A, IGF-IEa and MMP-2 genes, while AAS administration or its combination with training reduced their expression. This study indicated that exercise did not alter the expression of collagen and related growth factors in different regions of rat tendon. Moreover, the pattern of gene expression was distinct in the different tendon regions of sedentary animals. Although, the RNA yield levels of CT, SFT and DFT were not distinct in each region, these regions possess not only the structural and biochemical difference, but also divergence in the expression of key genes involved in tendon adaptation.
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Registered trials
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