ArticleHistochemistry and cell biology2011
Nuclear lamins are differentially expressed in retinal neurons of the adult rat retina.
Article in Histochemistry and cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression.International journal of molecular sciences · 2020Article
- Differential Expression of LaminB1 in the Developing Rat Cochlea.The journal of international advanced otology · 2019Article
- Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex.IBRO reports · 2018Article
- Altered Lamin A/C splice variant expression as a possible diagnostic marker in breast cancer.Cellular oncology (Dordrecht, Netherlands) · 2016Article
- Do lamin A and lamin C have unique roles?Chromosoma · 2015Review
- The expression analysis of Sfrs10 and Celf4 during mouse retinal development.Gene expression patterns : GEP · 2013Article
- Nuclear lamins in the brain - new insights into function and regulation.Molecular neurobiology · 2013Review
- Prolonged expression of Puma in cholinergic amacrine cells during the development of rat retina.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- Recent progress in histochemistry and cell biology.Histochemistry and cell biology · 2012Review
- Developmental regulation of linkers of the nucleoskeleton to the cytoskeleton during mouse postnatal retinogenesis.Nucleus (Austin, Tex.)Article
- When untethered, something silent inside comes.Nucleus (Austin, Tex.)Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lamins are type V intermediate filament proteins that support nuclear membranes. They are divided into A-type lamins, which include lamin A and C, and B-type lamins, which include lamin B1 and B2. In the rat brain, lamin A and C are expressed in relatively equal amounts, while the expressions of lamin B1 and B2 vary depending on the cell type. Lamins play important roles in normal morphogenesis and function. In the nervous system, their abnormal expression causes several neurodegenerative diseases such as peripheral neuropathy, leukodystrophy and lissencephaly. The retina belongs to the central nervous system (CNS) and has widely been used as a source of CNS neurons. We investigated the expression patterns of lamin subtypes in the adult rat retina by immunohistochemistry and found that the staining patterns differed when compared with the brain. All retinal neurons expressed lamin B1 and B2 in relatively equal amounts. In addition, horizontal cells and a subpopulation of retinal ganglion cells expressed lamin A and C, while photoreceptor cells expressed neither lamin A nor C, and all other retinal neurons expressed lamin C only. This differential expression pattern of lamins in retinal neurons suggests that they may be involved in cellular differentiation and expression of cell-specific genes in individual retinal neurons.
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