ReviewCellular and molecular life sciences : CMLS2012
How to find your way through the thymus: a practical guide for aspiring T cells.
Review in Cellular and molecular life sciences : CMLS, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Spatial cartography of human thymus enables the geopositioning of lineage transcription factors in rare mimetic thymic epithelial cells.Nature communications · 2026Article
- Thymic hyperplasia in myasthenia gravis: a narrative review.Mediastinum (Hong Kong, China) · 2025Review
- T cell-expressed Ift88 is required for proper thymocyte differentiation in mice.Physiological reports · 2024Article
- Type I interferon induced during chronic viral infection favors B-cell development in the thymus.Immunology and cell biology · 2024Article
- [Pure white cell aplasia combined with thymoma and lung cancer: a case report and literature review].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Review
- Environmental endocrine disruptors and amphibian immunity: A bridge between the thyroid hormone axis and T cell development.Developmental and comparative immunology · 2023Article
- Reading the Ts and DCs of thymopoiesis.Nature immunology · 2023Article
- Clinical Practice Guidelines for the Immunological Management of Chromosome 22q11.2 Deletion Syndrome and Other Defects in Thymic Development.Journal of clinical immunology · 2023Review
- The impact of the gut microbiota on T cell ontogeny in the thymus.Cellular and molecular life sciences : CMLS · 2022Review
- Congenital Athymia: Genetic Etiologies, Clinical Manifestations, Diagnosis, and Treatment.Journal of clinical immunology · 2021Review
- Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.Frontiers in immunology · 2020Article
- A Rare Complication of Thymoma: Pure White Cell Aplasia in Good's Syndrome.Case reports in hematology · 2019Article
- Real Time In Vivo Tracking of Thymocytes in the Anterior Chamber of the Eye by Laser Scanning Microscopy.Journal of visualized experiments : JoVE · 2018Article
- Making Thymus Visible: Understanding T-Cell Development from a New Perspective.Frontiers in immunology · 2018Article
- Normal Thymocyte Egress, T Cell Trafficking, and CD4Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Article
- Enhancement of rag1 and tdt expression in thymus after immunization.Doklady. Biochemistry and biophysics · 2015Article
- Paraneoplastic disorders in thymoma patients.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2014Review
- Article
- X-ray irradiation selectively kills thymocytes of different stages and impairs the maturation of donor-derived CD4(+)CD8(+) thymocytes in recipient thymus.Journal of biomedical research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Thymocytes must complete an elaborate developmental program in the thymus to ultimately generate T cells that express functional but neither harmful nor useless TCRs. Each developmental step coincides with dynamic relocation of the thymocytes between anatomically discrete thymic microenvironments, suggesting that thymocytes' migration is tightly regulated by their developmental status. Chemokines produced by thymic stromal cells and chemokine receptors on the thymocytes play an indispensable role in guiding developing thymocytes into the different microenvironments. In addition to long-range migration, chemokines increase the thymocytes' motility, enhancing their interaction with stromal cells. During the past several years, much progress has been made to determine the various signals that guide thymocytes on their journey within the thymus. In this review, we summarize the progress in identifying chemokines and other chemoattractant signals that direct intrathymic migration. Furthermore, we discuss the recent advances of two-photon microscopy in determining dynamic motility and interaction behavior of thymocytes within distinct compartments to provide a better understanding of the relationship between thymocyte motility and development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.