ArticleParasitology research2012
Identification and partial characterization of a serine protease inhibitor (serpin) of Eimeria tenella.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular characterization and protective efficacy of silent information regulator 2A from Eimeria tenella.Parasites & vectors · 2016Trial
- EtSERPIN1 binding with chicken ANXA2 is essential for Eimeria tenella attachment and invasion process.Veterinary research · 2025Article
- Combined transcriptome and whole genome sequencing analyses reveal candidate drug-resistance genes ofiScience · 2025Article
- Eimeria proteins: order amidst disorder.Parasites & vectors · 2022Review
- Global transcriptome landscape of the rabbit protozoan parasite Eimeria stiedae.Parasites & vectors · 2021Article
- Dynamically expressed genes provide candidate viability biomarkers in a model coccidian.PloS one · 2021Article
- Molecular characterization and protective efficacy of a new conserved hypothetical protein of Eimeria tenella.Parasite (Paris, France) · 2021Article
- A Novel Rhoptry Protein as Candidate Vaccine againstVaccines · 2020Article
- Molecular characterization and immune protection of an AN1-like zinc finger protein of Eimeria tenella.Parasitology research · 2020Article
- Article
- Molecular characterization of surface antigen 10 of Eimeria tenella.Parasitology research · 2019Article
- Molecular characterization and functional analysis of Eimeria tenella malate dehydrogenase.Parasitology research · 2018Article
- Identification of an interaction between calcium-dependent protein kinase 4 (EtCDPK4) and serine protease inhibitor (EtSerpin) in Eimeria tenella.Parasites & vectors · 2018Article
- Molecular characterization and protective efficacy of the microneme 2 protein from Eimeria tenella.Parasite (Paris, France) · 2018Article
- Molecular Characterization and Functional Analysis of a Novel Calcium-Dependent Protein Kinase 4 from Eimeria tenella.PloS one · 2016Article
- Molecular Characterization and Immune Protection of a New Conserved Hypothetical Protein of Eimeria tenella.PloS one · 2016Article
- Effect of diclazuril on intestinal morphology and SIgA expression in chicken infected with Eimeria tenella.Parasitology research · 2014Article
- Molecular cloning and characterization of lactate dehydrogenase gene from Eimeria tenella.Parasitology research · 2014Article
- Identification and characterization of an Eimeria-conserved protein in Eimeria tenella.Parasitology research · 2014Article
- Molecular characterization and analysis of a novel protein disulfide isomerase-like protein of Eimeria tenella.PloS one · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serine protease inhibitors (serpins) mediate many biological processes, including immune responses to pathogenic infection. In this study, a member of the serpin superfamily was identified from the common poultry parasite Eimeria tenella by expressed sequence tag analysis and the rapid amplification of cDNA ends technique. The full-length cDNA was 1,918 bp and had an open reading frame of 1,248 bp encoding a polypeptide of 415 amino acids with the theoretical isoelectric point of 5.26 and predicted molecular weight of 45.5 kDa. Real-time quantitative PCR analysis revealed that the serpin gene was expressed at higher levels in sporozoites than in the other developmental stages (unsporulated oocysts, sporulated oocysts, and second-generation merozoites). The sequence encoding the mature protein was amplified by PCR, cloned into the pET28(a) vector, and expressed in Escherichia coli. Specific antiserum generated against the recombinant protein was prepared and used to determine invasion inhibition capacity and localization; the results suggested that the serpin may play an important role in invasion and survival of the sporoziotes in the host.
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