Evidence map›Paper›PMID 21842258›Full record

ReviewCurrent urology reports2011

Stem cell therapy for incontinence: where are we now? What is the realistic potential?

Charuspong Dissaranan, Michelle A Cruz, Bruna M Couri, Howard B Goldman, Margot S Damaser

Open access · greenAbstract readReview
In one paragraph

Review in Current urology reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Small activating RNA induces myogenic differentiation of rat adipose-derived stem cells by upregulating MyoD.International braz j urol : official journal of the Brazilian Society of Urology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Charuspong DissarananGlickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Michelle A Cruz
Bruna M Couri
Howard B Goldman
Margot S Damaser
Cleveland Clinic · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
MECHANISMS OF INCONTINENCE FOLLOWING VAGINAL DISTENSIONR01HD038679 · NICHD · LOYOLA UNIVERSITY CHICAGO · PI DAMASER, MARGOT S. · 2000 to 2010
$2.7M
Stem Cell Homing for Treatment of Female Pelvic Floor DisordersR01HD059859 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI DAMASER, MARGOT S. · 2010 to 2014
$1.6M
NCRR NIH HHS UL1 RR024989NICHD NIH HHS R01 HD038679NICHD NIH HHS R01 HD059859
6 · The paper itself

Abstract

A significant number of women experience stress urinary incontinence (SUI), which greatly affects their quality of life. Recent research investigating utilization of stem cells and their derivatives for the prevention and treatment of SUI has been performed to test the effect of cell source and method of administration in several animal models of SUI. The type of stem cell, timing of optimal dose or doses after injury, mechanism of action of stem cells, and route of administration must be investigated both preclinically and clinically before stem cell therapy becomes a possible treatment for SUI, although the future of this therapy looks promising. This article reviews the progress in stem cell research for incontinence and describes areas of future work as suggested by research in other fields.

Indexed as

Stem Cell TransplantationAdipocytesFemaleHumansMyoblastsUrinary Incontinence, Stress

Identifiers

PMID21842258
PMCPMC3218558
OpenAlexW1986396379

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.