Trial reportJournal of gastroenterology2011
Fever-based antibiotic therapy for acute cholangitis following successful endoscopic biliary drainage.
Trial report in Journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- ShortWorld journal of gastroenterology · 2023Pooled it
- Antibiotic Therapy of 3 Days May Be Sufficient After Biliary Drainage for Acute Cholangitis: A Systematic Review.Digestive diseases and sciences · 2021Pooled it
- 2020 WSES guidelines for the detection and management of bile duct injury during cholecystectomy.World journal of emergency surgery : WJES · 2021Guideline
- Short-Course Antibiotic Treatment Is Not Inferior to a Long-Course One in Acute Cholangitis: A Systematic Review.Digestive diseases and sciences · 2019Pooled it
- Early oral antibiotic switch compared with conventional intravenous antibiotic therapy for acute cholangitis with bacteremia.Digestive diseases and sciences · 2014Trial
- Article
- Article
- Navigating antibiotic therapy in acute cholangitis: Best practices and new insights.Journal of hepato-biliary-pancreatic sciences · 2025Review
- Comparison of antimicrobial therapy termination in febrile and afebrile patients with acute cholangitis after drainage.Scientific reports · 2024Article
- Article
- ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients.Experimental and therapeutic medicine · 2024Article
- Article
- Association of short-course antimicrobial therapy and bacterial resistance in acute cholangitis: Retrospective cohort study.Endoscopy international open · 2024Article
- Antibiotic Administration within Two Days after Successful Endoscopic Retrograde Cholangiopancreatography Is Sufficient for Mild and Moderate Acute Cholangitis.Journal of clinical medicine · 2022Article
- Validation of TG07 and TG13/TG18 criteria for acute cholangitis and predictors of in-hospital mortality in patients over 80 years old.Clinical and experimental hepatology · 2021Article
- Impact of the Sensitivity to Empiric Antibiotics on Clinical Outcomes after Biliary Drainage for Acute Cholangitis.Gut and liver · 2020Article
- Antimicrobial therapy of 3 days or less is sufficient after successful ERCP for acute cholangitis.United European gastroenterology journal · 2020Article
- No Association of Timing of Endoscopic Biliary Drainage with Clinical Outcomes in Patients with Non-severe Acute Cholangitis.Digestive diseases and sciences · 2018Article
- Top Questions in Uncomplicated, Non-Open forum infectious diseases · 2018Article
- Cholangitis: Diagnosis, Treatment and Prognosis.Journal of clinical and translational hepatology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe current management of acute cholangitis consists of antibiotic therapy in combination with biliary drainage. However, the optimal duration of antibiotic therapy after the resolution of clinical symptoms by biliary drainage is unclear. We aimed to evaluate whether discontinuing antibiotic therapy for acute cholangitis immediately after the resolution of clinical symptoms, achieved by endoscopic biliary drainage, was safe and effective.
methodsThis prospective study included patients with moderate and severe acute cholangitis. Cefmetazole sodium and meropenem hydrate were used as initial antibiotic therapy for patients with moderate and severe acute cholangitis, respectively. All patients underwent endoscopic biliary drainage within 24 h of diagnosis. When the body temperature of < 37 ° C was maintained for 24 h, administration of antibiotics was stopped. The primary endpoint was the recurrence of acute cholangitis within 3 days after the withdrawal of antibiotic therapy.
resultsEighteen patients were subjected to the final analysis. The causes of cholangitis were bile duct stone (n = 17) and bile duct cancer (n = 1). The severity of acute cholangitis was moderate in 14 patients and severe in 4. Body temperature of < 37 ° C was achieved in all patients after a median of 2 days (range 1-6) following endoscopic biliary drainage. Antibiotic therapy was administered for a median duration of 3 days (range 2-7). None of the patients developed recurrent cholangitis within 3 days after the withdrawal of antibiotics.
conclusionsFever-based antibiotic therapy for acute cholangitis is safe and effective when resolution of fever is achieved following endoscopic biliary drainage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.