Trial reportClinical oral investigations2012
Long-term effectiveness of four pulpotomy techniques: 3-year randomised controlled trial.
Trial report in Clinical oral investigations, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05792748 (A Clinical Trial Comparing Reinforced Zinc Oxide Eugenol to Ferric Sulphate as a Pulpotomy Agent in Primary Teeth), which is not on this map. Cited by 28 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Clinical Trial Comparing Reinforced Zinc Oxide Eugenol to Ferric Sulphate as a Pulpotomy Agent in Primary Teeth
Who cites it
28 citing papers in PubMed, 6 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Assessing the efficacy of Laser pulpotomy versus conventional pulpotomy in primary teeth: A systematic review and meta-analysis of clinical trials.Lasers in medical science · 2024Pooled it
- Contemporary management of deep caries in primary teeth: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Efficacy of ferric sulphate as a pulpotomy medicament in primary molars: an evidence based approach.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2018Pooled it
- Laser pulpotomy-an effective alternative to conventional techniques-a systematic review of literature and meta-analysis.Lasers in medical science · 2018Pooled it
- Clinical and radiographic outcomes of laser pulpotomy in vital primary teeth: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2018Pooled it
- Evidence of pulpotomy in primary teeth comparing MTA, calcium hydroxide, ferric sulphate, and electrosurgery with formocresol.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2015Pooled it
- Comparative evaluation of the success of Er,Cr:YSGG laser, ferric sulfate, or a herbal hemostatic agent for hemostasis in primary molar pulpotomy.European journal of oral sciences · 2025Trial
- Comparison between calcium hydroxide mixtures and mineral trioxide aggregate in primary teeth pulpotomy: a randomized controlled trial.Journal of applied oral science : revista FOB · 2019Trial
- Low-level laser therapy as an alternative for pulpotomy in human primary teeth.Lasers in medical science · 2015Trial
- Clinical decision-making in pulp therapy of primary teeth among Tunisian dental practitioners: a cross-sectional study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Long-term Outcomes of Invasive Pulp Therapies in Primary Teeth: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistry · 2026Article
- Laser Pulpotomies' Clinical and Radiographic Success in Primary Teeth by Type of Laser.Children (Basel, Switzerland) · 2025Review
- Effectiveness of Diode Lasers as an Adjunct in Pulpotomy Procedures Involving Primary Teeth: A Systematic Review.International journal of clinical pediatric dentistry · 2025Article
- Pediatric Preformed Zirconium Oxide Crowns vs. Preformed Metal Crowns After Pulpotomy in Primary Molars: A Practice-Based Retrospective 2.5 Year Cohort Study.Healthcare (Basel, Switzerland) · 2025Article
- Pulpotomy in primary teeth: Biodentine™ versus calcium hydroxide. A systematic review and meta-analysis.The Saudi dental journal · 2024Review
- Clinical and Radiographic Efficacy of Low-level Laser Therapy and Formocresol as Pulpotomy Agents in Primary Molars: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistry · 2024Article
- Hyaluronic acid as a pulpotomy material in primary molars: an up to 30 months retrospective study.BMC oral health · 2024Article
- The application of lasers in vital pulp therapy: clinical and radiographic outcomes.BMC oral health · 2024Review
- The application of lasers in vital pulp therapy: a review of histological effects.Lasers in medical science · 2023Review
- Pulp Therapy of Primary Dentition; its Relevance despite Insufficient Histological Evidence: A Review.Iranian endodontic journal · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A pulpotomy is the therapy for management of pulp exposures due to caries in symptom-free primary molars. The aim was to longitudinally compare the relative effectiveness of the Er:YAG laser, calcium hydroxide and ferric sulphate techniques with dilute formocresol in retaining symptom-free molars. Two hundred primary molars in 107 healthy children were included and randomly allocated to one technique. The treated teeth were blindly reevaluated after 6, 12, 18, 24 and 36 months. Descriptive data analysis and logistic regression analysis accounting for multiple observations per patient by generalised estimating equation were used. Additionally, various influences including tooth type, upper and lower jaws, type of anaesthesia, operator and the final restoration on treatment success were evaluated (Wald chi-square test). After 36 months, the following total (considering clinical and clinically symptom-free radiographic failures) and clinical success rates were determined (in percent): Formocresol 72 (92), laser 73 (89), calcium hydroxide 46 (75), ferric sulphate 76 (97). No significant differences were detected between formocresol and any other technique after 36 months. However, the odds ratio of failure appeared to be three times higher for calcium hydroxide than for formocresol. No significant differences in total success rates were seen regarding the aforementioned influencing clinical parameters. The correct diagnosis of the pulpal status, bleeding control and the specific technique are highly important for long-term success of pulpotomies in primary molars. According to the presented long-term data, pulpotomies using ferric sulphate revealed the best treatment outcome among the used techniques, while calcium hydroxide resulted in the lowest success rates after 3 years. Therefore, we can recommend ferric sulphate for easy and successful treatment of primary molars with caries-exposed pulps.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.